ArticleBiological research2015
Tridax procumbens flavonoids promote osteoblast differentiation and bone formation.
Article in Biological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate.Cell biochemistry and biophysics · 2024Article
- Minimal Inhibitory Concentration Assay ofJournal of pharmacy & bioallied sciences · 2024Article
- Retraction Note: Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation.Biological research · 2023Article
- Bone morphogenetic protein 4 is involved in cadmium-associated bone damage.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss.Nutrients · 2023Review
- In vitro and in vivo investigation of chrysin chelated copper complex as biocompatible materials for bone tissue engineering applications.3 Biotech · 2023Article
- Flavonoids fromJournal of dental sciences · 2023Article
- Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components.Materials (Basel, Switzerland) · 2021Review
- ProbioticMicroorganisms · 2021Article
- Flavonoids compounds from Tridax procumbens inhibit osteoclast differentiation by down-regulating c-Fos activation.Journal of cellular and molecular medicine · 2020Article
- The effects of mumie extract on cell proliferation and enzyme expression of human osteoblast-like cells (MG63).Journal of stem cells & regenerative medicine · 2019Article
- Syringic acid, a phenolic acid, promotes osteoblast differentiation by stimulation of Runx2 expression and targeting of Smad7 by miR-21 in mouse mesenchymal stem cells.Journal of cell communication and signaling · 2018Article
- Green Tea Polyphenols Coupled with a Bioactive Titanium Alloy Surface: In Vitro Characterization of Osteoinductive Behavior through a KUSA A1 Cell Study.International journal of molecular sciences · 2018Article
- Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation.Biological research · 2017Article
- The effects of morin on bone regeneration to accelerate healing in bone defects in mice.International journal of immunopathology and pharmacologyArticle
- Mechanism of vasorelaxation induced by Tridax procumbens extract in rat thoracic aorta.Journal of intercultural ethnopharmacologyArticle
Corrections and comments
- Retraction · 2024-06-24Lack of IRB/IACUC Approval and/or Compliance ·
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTridax procumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, piles, and urinary problems, it is also used in treating gastric problems, body pain, and rheumatic pains of joints. TPFs have been reported to increase osteogenic functioning in mesenchymal stem cells. Our previous study showed that TPFs were significantly suppressed the RANKL-induced differentiation of osteoclasts and bone resorption. However, the effects of TPFs to promote osteoblasts differentiation and bone formation remain unclear. TPFs were isolated from Tridax procumbens and investigated for their effects on osteoblasts differentiation and bone formation by using primary mouse calvarial osteoblasts.
resultsTPFs promoted osteoblast differentiation in a dose-dependent manner demonstrated by up-regulation of alkaline phosphatase and osteocalcin. TPFs also upregulated osteoblast differentiation related genes, including osteocalcin, osterix, and Runx2 in primary osteoblasts. TPFs treated primary osteoblast cells showed significant upregulation of bone morphogenetic proteins (BMPs) including Bmp-2, Bmp-4, and Bmp-7. Addition of noggin, a BMP specific-antagonist, inhibited TPFs induced upregulation of the osteocalcin, osterix, and Runx2.
conclusionOur findings point towards the induction of osteoblast differentiation by TPFs and suggested that TPFs could be a potential anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.