ArticleNanotoxicology2016
Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation.
Article in Nanotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- SiOScientific reports · 2025Article
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- An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform.Nanomaterials (Basel, Switzerland) · 2022Article
- Ethyl Hydroxyethyl Cellulose-A Biocompatible Polymer Carrier in Blood.International journal of molecular sciences · 2022Article
- Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.Coordination chemistry reviews · 2022Review
- Parametric Optimization of an Air-Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeONanomaterials (Basel, Switzerland) · 2020Article
- The investigation of the parameters affecting the ZnO nanoparticle cytotoxicity behaviour: a tutorial review.Biomaterials science · 2020Review
- Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials.Bioactive materials · 2020Article
- Isolation methods for particle protein corona complexes from protein-rich matrices.Nanoscale advances · 2020Review
- Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.Particle and fibre toxicology · 2020Article
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- Nanoparticle induced barrier function assessment at liquid-liquid and air-liquid interface in novel human lung epithelia cell lines.Toxicology research · 2019Article
- Global diffusion limitations during the initial phase of the formation of a protein corona around nanoparticles.Journal of biological physics · 2019Article
- Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs.Particle and fibre toxicology · 2018Review
- Article
- Preparation and Characterization of WS₂@SiO₂ and WS₂@PANI Core-Shell Nanocomposites.Nanomaterials (Basel, Switzerland) · 2018Article
- Nanoparticle exposures from nano-enabled toner-based printing equipment and human health: state of science and future research needs.Critical reviews in toxicology · 2017Review
- Nanoparticle Functionalization and Its Potentials for Molecular Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Review
- Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
Nanoparticle (NP) pharmacokinetics and biological effects are influenced by many factors, especially surface physicochemical properties. We assessed the effects of an amorphous silica coating on the fate of zinc after intravenous (IV) injection of neutron activated uncoated (65)ZnO or silica-coated (65)ZnO NPs in male Wistar Han rats. Groups of IV-injected rats were sequentially euthanized, and 18 tissues were collected and analyzed for (65)Zn radioactivity. The protein coronas on each ZnO NP after incubation in rat plasma were analyzed by SDS-PAGE gel electrophoresis and mass spectrometry of selected gel bands. Plasma clearance for both NPs was biphasic with rapid initial and slower terminal clearance rates. Half-lives of plasma clearance of silica-coated (65)ZnO were shorter (initial - <1 min; terminal - 2.5 min) than uncoated (65)ZnO (initial - 1.9 min; terminal - 38 min). Interestingly, the silica-coated (65)ZnO group had higher (65)Zn associated with red blood cells and higher initial uptake in the liver. The (65)Zn concentrations in all the other tissues were significantly lower in the silica-coated than uncoated groups. We also found that the protein corona formed on silica-coated ZnO NPs had higher amounts of plasma proteins, particularly albumin, transferrin, A1 inhibitor 3, α-2-hs-glycoprotein, apoprotein E and α-1 antitrypsin. Surface modification with amorphous silica alters the protein corona, agglomerate size, and zeta potential of ZnO NPs, which in turn influences ZnO biokinetic behavior in the circulation. This emphasizes the critical role of the protein corona in the biokinetics, toxicology and nanomedical applications of NPs.
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Registered trials
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