ArticleBMC genomics2015
Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Characterization of scp3 and Its Expression Dynamics Identifies the Critical Period for Meiotic Initiation in Female Turbot (Scophthalmus maximus).Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Specialization of the upper and lower olfactory rosettes reveals sex- and origin-dependent plasticity in gene expression in Senegalese sole (Solea senegalensis).BMC biology · 2026Article
- Sex- and stage-dependent expression of gonadal soma-derived factor paralogues reveals functional and evolutionary divergence in European sea bass (Frontiers in endocrinology · 2026Article
- Dietary Soy Isoflavones Promote Feminization and Enhance Growth of Juvenile Japanese Eel (Animals : an open access journal from MDPI · 2025Article
- Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis.Biology of sex differences · 2022Article
- A Transcriptomic Analysis of Gonads from the Low-Temperature-Induced Masculinization ofAnimals : an open access journal from MDPI · 2021Article
- Clustering of Sex-Biased Genes and Transposable Elements in the Genome of the Medaka Fish Oryzias latipes.Genome biology and evolution · 2021Article
- Differential expression analysis and identification of sex-related genes by gonad transcriptome sequencing in estradiol-treated and non-treated Ussuri catfish Pseudobagrus ussuriensis.Fish physiology and biochemistry · 2021Article
- Sexual Development of the Hermaphroditic ScallopFrontiers in cell and developmental biology · 2021Article
- Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor.Frontiers in cell and developmental biology · 2021Review
- Comparative Genomics Studies on theFrontiers in genetics · 2020Article
- Effects of short-time exposure to atrazine on miRNA expression profiles in the gonad of common carp (Cyprinus carpio).BMC genomics · 2019Article
- Transcriptome of Gonads From High Temperature Induced Sex Reversal During Sex Determination and Differentiation in Chinese Tongue Sole,Frontiers in genetics · 2019Article
- Transcriptome Profiling Insights the Feature of Sex Reversal Induced by High Temperature in Tongue SoleFrontiers in genetics · 2019Article
- Highly dense linkage maps from 31 full-sibling families of turbot (Scophthalmus maximus) provide insights into recombination patterns and chromosome rearrangements throughout a newly refined genome assembly.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis.BMC genomics · 2018Article
- FOXL2 and DMRT1L Are Yin and Yang Genes for Determining Timing of Sex Differentiation in the Bivalve MolluskFrontiers in physiology · 2018Article
- Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Differential gene expression and SNP association between fast- and slow-growing turbot (Scophthalmus maximus).Scientific reports · 2017Article
- Identification and profiling of Cyprinus carpio microRNAs during ovary differentiation by deep sequencing.BMC genomics · 2017Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControlling sex ratios is essential for the aquaculture industry, especially in those species with sex dimorphism for relevant productive traits, hence the importance of knowing how the sexual phenotype is established in fish. Turbot, a very important fish for the aquaculture industry in Europe, shows one of the largest sexual growth dimorphisms amongst marine cultured species, being all-female stocks a desirable goal for the industry. Although important knowledge has been achieved on the genetic basis of sex determination (SD) in this species, the master SD gene remains unknown and precise information on gene expression at the critical stage of sex differentiation is lacking. In the present work, we examined the expression profiles of 29 relevant genes related to sex differentiation, from 60 up to 135 days post fertilization (dpf), when gonads are differentiating. We also considered the influence of three temperature regimes on sex differentiation.
resultsThe first sex-related differences in molecular markers could be observed at 90 days post fertilization (dpf) and so we have called that time the onset of sex differentiation. Three genes were the first to show differential expression between males and females and also allowed us to sex turbot accurately at the onset of sex differentiation (90 dpf): cyp19a1a, amh and vasa. The expression of genes related to primordial germ cells (vasa, gsdf, tdrd1) started to increase between 75-90 dpf and vasa and tdrd1 later presented higher expression in females (90-105 dpf). Two genes placed on the SD region of turbot (sox2, fxr1) did not show any expression pattern suggestive of a sex determining function. We also detected changes in the expression levels of several genes (ctnnb1, cyp11a, dmrt2 or sox6) depending on culture temperature.
conclusionOur results enabled us to identify the first sex-associated genetic cues (cyp19a1a, vasa and amh) at the initial stages of gonad development in turbot (90 dpf) and to accurately sex turbot at this age, establishing the correspondence between gene expression profiles and histological sex. Furthermore, we profiled several genes involved in sex differentiation and found specific temperature effects on their expression.
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