Evidence map›Paper›PMID 26581102›Full record

ArticlePloS one2015

Metabolic Characterization of the Common Marmoset (Callithrix jacchus).

Young-Mi Go, Yongliang Liang, Karan Uppal, Quinlyn A Soltow, Daniel E L Promislow, Lynn M Wachtman, Dean P Jones

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2019
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  12. Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018
    Article
  13. Review
  14. Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria.International journal of medical microbiology : IJMM · 2017
    Article
  15. Article
  16. Article
  17. Article
  18. Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2016
    Article
  19. Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.Journal of occupational and environmental medicine · 2016
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Young-Mi GoDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia, 30322, United States of America.
Yongliang LiangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia, 30322, United States of America.
Karan UppalDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia, 30322, United States of America.
Quinlyn A SoltowDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia, 30322, United States of America.
Daniel E L PromislowDepartment of Pathology and Department of Biology, University of Washington, Seattle, Washington, 98195, United States of America.
Lynn M WachtmanNew England Primate Research Center, Harvard University, Southborough, Massachusetts, 01772, United States of America.
Dean P JonesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Clinical Biomarkers Laboratory, Emory University, Atlanta, Georgia, 30322, United States of America.
Emory University · USUniversity of Washington · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
Metabolomics of subclinical and clinical cardiovascular diseaseP20HL113451 · NHLBI · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2012 to 2016
$4.3M
A metabolomic model of aging in the common marmosetR01AG038746 · NIA · EMORY UNIVERSITY · PI JONES, DEAN PAUL, PROMISLOW, DANIEL EDWARD · 2010 to 2014
$2.5M
Cytoplasmic-nuclear redox signaling: Disruption by dietary cadmium levelsR01ES023485 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2014 to 2018
$1.8M
Orbitrap Elite/H-ESI BundleS10OD018006 · OD · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2014 to 2014
$600k
Mitochondria Environmental Stress Signaling NetworksR21ES025632 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2015 to 2017
$576k
NHLBI NIH HHS HL113451NHLBI NIH HHS P20 HL113451NIA NIH HHS AG038746NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG038746NIEHS NIH HHS ES019776NIEHS NIH HHS ES023485NIEHS NIH HHS ES 025632NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES023485NIEHS NIH HHS R21 ES025632NIEHS NIH HHS T32 ES012870NIH HHS OD018006NIH HHS S10 OD018006
6 · The paper itself

Abstract

High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild populations. In a previous non-targeted metabolomics study of common marmosets (Callithrix jacchus), Rhesus macaques, humans, and four non-primate mammalian species, we found that essential amino acids (AA) and other central metabolites had interspecies variation similar to intraspecies variation while non-essential AA, environmental chemicals and catabolic waste products had greater interspecies variation. The present study was designed to test whether 55 plasma metabolites, including both nutritionally essential and non-essential metabolites and catabolic products, differ in concentration in common marmosets and humans. Significant differences were present for more than half of the metabolites analyzed and included AA, vitamins and central lipid metabolites, as well as for catabolic products of AA, nucleotides, energy metabolism and heme. Three environmental chemicals were present at low nanomolar concentrations but did not differ between species. Sex and age differences in marmosets were present for AA and nucleotide metabolism and warrant additional study. Overall, the results suggest that quantitative, targeted metabolomics can provide a useful complement to non-targeted metabolomics for studies of diet and environment interactions in primate evolution.

Indexed as

MetabolomicsAge FactorsAmino AcidsAnimalsCallithrixChromatography, LiquidFemaleHemeLipidsMaleMass SpectrometryMetabolic Networks and PathwaysMetabolomeNucleotidesSex FactorsVitaminsAmino AcidsHemeLipidsNucleotidesVitamins

Identifiers

PMID26581102
PMCPMC4651467
OpenAlexW2178015804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.