Evidence map›Paper›PMID 26580862›Full record

ReviewAnnals of neurology2016

Tranexamic acid-associated seizures: Causes and treatment.

Irene Lecker, Dian-Shi Wang, Paul D Whissell, Sinziana Avramescu, C David Mazer, Beverley A Orser

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05554211 (Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage), which is not on this map. Cited by 93 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 9 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05554211 phase2withdrawnnot on this mapstarted 2022, after this paper: background citation

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

TypeinterventionalSponsorNorthwestern UniversityRan2022 to 2024Enrolled0ConditionsBreast Cancer, BRCA MutationArmsTranexamic acid, Normal saline
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 9 syntheses or guidelines pooled it, 266 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Safety and effectiveness of EvicelChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Trial
  12. [Efficacy and safety of tranexamic acid sequential rivaroxaban on blood loss in elderly patients during lumbar interbody fusion].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Irene LeckerDepartments of Physiology, University of Toronto.
Dian-Shi WangDepartments of Physiology, University of Toronto.
Paul D WhissellPsychology, University of Toronto.
Sinziana AvramescuAnesthesia, University of Toronto.
C David MazerDepartments of Physiology, University of Toronto.
Beverley A OrserDepartments of Physiology, University of Toronto.
University of Toronto · CASt Michaels Hospital · GBSt. Michael's Hospital · CA

Funding

Canadian Institutes of Health Research MOP-38028Canadian Institutes of Health Research MOP-79428
6 · The paper itself

Abstract

Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postoperative seizures. The reported increase in the frequency of seizures is alarming, as these events are associated with adverse neurological outcomes, longer hospital stays, and increased in-hospital mortality. However, many clinicians are unaware that tranexamic acid causes seizures. The goal of this review is to summarize the incidence, risk factors, and clinical features of these seizures. This review also highlights several clinical and preclinical studies that offer mechanistic insights into the potential causes of and treatments for tranexamic acid-associated seizures. This review will aid the medical community by increasing awareness about tranexamic acid-associated seizures and by translating scientific findings into therapeutic interventions for patients.

Indexed as

AnimalsAntifibrinolytic AgentsHumansSeizuresTranexamic AcidAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID26580862
PMCPMC4738442
OpenAlexW2174657578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.