Evidence map›Paper›PMID 26580327›Full record

ReviewNature2015

Global neurotrauma research challenges and opportunities.

Andrés M Rubiano, Nancy Carney, Randall Chesnut, Juan Carlos Puyana

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06787040 (Beyond One Option for the Treatment of Severe Traumatic Brain Injury [BOOTStraP]), which is not on this map. Cited by 238 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06787040 completednot on this mapstarted 2024, after this paper: background citation

Beyond One Option for the Treatment of Severe Traumatic Brain Injury [BOOTStraP]: A Pilot Study

Typeobservational_patient_registrySponsorMeditech FoundationRan2024 to 2025Enrolled96ConditionsTraumatic Brain InjuryArmsResource-Stratified Protocol
3 · Its place in the literature

Who cites it

238 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pediatric traumatic brain injury prehospital guidelines: a systematic review and appraisal.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Pooled it
  5. Pooled it
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  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
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  13. Survival status, mortality predictors, and scores in patients with severe traumatic brain injury in the intensive care unit.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026
    Article
  14. Article
  15. Article
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  17. Review
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178 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrés M RubianoNeuroscience Institute, Neurotrauma Group, El Bosque University, Avenue Carrera 9a, 131A-02, Edificio Fundadores, Bogotá, Colombia.
Nancy CarneyDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.
Randall ChesnutNeurological Surgery Global Health, Harborview Medical Center, Department of Neurosurgery, 325 Ninth Avenue, Seattle, Washington 98104, USA.
Juan Carlos PuyanaSurgery Critical Care Medicine and Clinical Translational Sciences Director of Global Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA.

Funding

Managing severe TBI without ICP monitoring - guidelines development and testingR01NS080648 · NINDS · UNIVERSITY OF WASHINGTON · PI CHESNUT, RANDALL M, LUJAN, SILVIA B · 2012 to 2018
$3.8M
eCapicity for Trauma Information Systems and Research Education (eCATIS)R25TW009714 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PUYANA, JUAN CARLOS · 2014 to 2016
$322k
Capacity Building for Decompressive Craniotomy in ColombiaR21TW009332 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PUYANA, JUAN CARLOS · 2012 to 2013
$187k
FIC NIH HHS R21 TW009332FIC NIH HHS R21TW009332-01A1FIC NIH HHS R25TW009714-01NINDS NIH HHS R01NS080648-01
6 · The paper itself

Abstract

Traumatic injury to the brain or spinal cord is one of the most serious public health problems worldwide. The devastating impact of 'trauma', a term used to define the global burden of disease related to all injuries, is the leading cause of loss of human potential across the globe, especially in low- and middle-income countries. Enormous challenges must be met to significantly advance neurotrauma research around the world, specifically in underserved and austere environments. Neurotrauma research at the global level needs to be contextualized: different regions have their own needs and obstacles. Interventions that are not considered a priority in some regions could be a priority for others. The introduction of inexpensive and innovative interventions, including mobile technologies and e-health applications, focused on policy management improvement are essential and should be applicable to the needs of the local environment. The simple transfer of a clinical question from resource-rich environments to those of low- and middle-income countries that lack sophisticated interventions may not be the best strategy to address these countries' needs. Emphasis on promoting the design of true 'ecological' studies that include the evaluation of human factors in relation to the process of care, analytical descriptions of health systems, and how leadership is best applied in medical communities and society as a whole will become crucial.

Indexed as

Brain InjuriesInternationalityBiomedical ResearchDeveloping CountriesHumansLeadership

Identifiers

PMID26580327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.