Evidence map›Paper›PMID 26580324›Full record

ReviewNature2015

Global research challenges and opportunities for mental health and substance-use disorders.

Florence Baingana, Mustafa al'Absi, Anne E Becker, Beverly Pringle

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706624 nacompletednot on this mapstarted 2021, after this paper: background citation

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2021 to 2025Enrolled667ConditionsMethamphetamine Abuse, Opioid-use Disorder, HIV SeropositivityArmsContingency management (12 weeks), Contingency management (6 weeks), SMS reminders, Matrix only, Matrix + Contingency management
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Stress across systems and lifespan: emerging biomarkers and mechanisms of resilience.Journal of neural transmission (Vienna, Austria : 1996) · 2025
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Florence BainganaMakerere University School of Public Health, PO Box 7072, Kampala, Uganda.
Mustafa al'AbsiDuluth Medical Research Institute (DMRI), University of Minnesota Medical School, 311-1035 University Drive, Duluth, Minnesota 55812, USA.
Anne E BeckerDepartment of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, Massachusetts 03115, USA.
Beverly PringleOffice for Research on Disparities &Global Mental Health, National Institute of Mental Health, 6001 Executive Boulevard, Room 7207, Bethesda, Maryland 20892, USA.

Funding

Stress, Appetite, and Smoking RelapseR01DA027232 · NIDA · UNIVERSITY OF MINNESOTA · PI AL'ABSI, MUSTAFA, LEE, DUSTIN CLARK · 2010 to 2025
$4.6M
Stress Response and Opioid Dysfunction in Nicotine DependenceR01DA016351 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2003 to 2023
$4.5M
Khat Research Program: Neurobehavioral Impact of Long-Term UseR21DA024626 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2009 to 2010
$283k
NIDA NIH HHS R01 DA016351NIDA NIH HHS R01DA016351NIDA NIH HHS R01 DA027232NIDA NIH HHS R01DA027232NIDA NIH HHS R21 DA024626NIDA NIH HHS R21DA024626
6 · The paper itself

Abstract

The research agenda for global mental health and substance-use disorders has been largely driven by the exigencies of high health burdens and associated unmet needs in low- and middle-income countries. Implementation research focused on context-driven adaptation and innovation in service delivery has begun to yield promising results that are improving the quality of, and access to, care in low-resource settings. Importantly, these efforts have also resulted in the development and augmentation of local, in-country research capacities. Given the complex interplay between mental health and substance-use disorders, medical conditions, and biological and social vulnerabilities, a revitalized research agenda must encompass both local variation and global commonalities in the impact of adversities, multi-morbidities and their consequences across the life course. We recommend priorities for research - as well as guiding principles for context-driven, intersectoral, integrative approaches - that will advance knowledge and answer the most pressing local and global mental health questions and needs, while also promoting a health equity agenda and extending the quality, reach and impact of scientific enquiry.

Indexed as

InternationalityMental HealthSubstance-Related DisordersBiomedical ResearchDelivery of Health CareHumans

Identifiers

PMID26580324
PMCPMC6368440

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.