Evidence map›Paper›PMID 26580323›Full record

ReviewNature2015

Nervous system disorders across the life course in resource-limited settings.

Gretchen L Birbeck, Ana-Claire Meyer, Adesola Ogunniyi

Abstract readReview
In one paragraph

Review in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Frontier and hot topics in Magnetoencephalography(MEG) in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  19. Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gretchen L BirbeckEpilepsy Division, Department of Neurology, University of Rochester, 265 Crittenden Boulevard, CU420694, Rochester, New York 14642-0694, USA.
Ana-Claire MeyerDepartment of Neurology, Yale University, P.O. Box 208018, New Haven, Connecticut, 06520-8018, USA.
Adesola OgunniyiDepartment of Medicine, University of Ibadan, PMB 5016, Ibadan 200001, Nigeria.

Funding

Treatment of HIV-Associated Cognitive ImpairmentK01TW008764 · FIC · YALE UNIVERSITY · PI MEYER, ANA-CLAIRE LEW · 2011 to 2015
$676k
FIC NIH HHS K01 TW008764
6 · The paper itself

Abstract

The resiliency of the adult nervous system is markedly affected by the environment and the circumstances during infant and child development. As such, adults in resource-limited settings who may have experienced early deprivation are particularly vulnerable to subsequent neurological disorders. Adult populations in countries with relatively recent advances in economic development may still have a higher susceptibility to neurological illness or injury that is reflective of the socioeconomic environment that was present during that population's infancy and childhood. Brain and peripheral nervous system research conducted over the past decade in resource-limited settings has led to an impressive and growing body of knowledge that informs our understanding of neurological function and dysfunction, independent of geography. Neurological conditions feature prominently in the burgeoning epidemic of non-communicable diseases facing low- and middle-income countries. Neurological research in these countries is needed to address this burden of disease. Although the burden of more prevalent and severe neurological disease poses public health and clinical challenges in settings with limited neurological expertise, the same factors, along with genetic heterogeneity and the relative absence of ingrained clinical care practices, offer circumstances well-suited for the conduct of crucial future research that is globally relevant.

Indexed as

AgingNervous System DiseasesResource AllocationAdultAgedBiomedical ResearchChildDeveloping CountriesHumans

Identifiers

PMID26580323
PMCPMC5845480

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.