Evidence map›Paper›PMID 26580322›Full record

ReviewNature2015

A focus on adolescence to reduce neurological, mental health and substance-use disability.

Leslie L Davidson, Elena L Grigorenko, Michael J Boivin, Elizabeth Rapa, Alan Stein

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Trial
  5. Converging etiopathogenetic pathways and early prevention opportunities for autism and neurodevelopmental disorders in the first 1000 days of life: a brief narrative review.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leslie L DavidsonDepartments of Epidemiology and Pediatrics, Mailman School of Public Health and College of Physicians and Surgeons, Columbia University, 722 West 168 Street Room 1613, New York, New York 10032, USA.
Elena L GrigorenkoChild Study Center, Department of Epidemiology and Public Health, Department of Psychology, Yale University, 230 South Frontage Road, New Haven, Connecticut 06519, USA.
Michael J BoivinDepartment of Psychiatry and Department of Neurology and Ophthalmology, College of Osteopathic Medicine, 965 Fee Road, Room A227, Michigan State University, East Lansing, Michigan 48824, USA.
Elizabeth RapaDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Alan SteinDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.

Funding

Health & Psychosocial Need: Children with Developmental Disorder in a Time of HIVR01DA023697 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAVIDSON, LESLIE L. · 2007 to 2011
$3.1M
NIDA NIH HHS R01 DA023697
6 · The paper itself

Abstract

Globally, there is a crucial need to prioritize research directed at reducing neurological, mental health and substance-use disorders in adolescence, which is a pivotal age for the development of self-control and regulation. In adolescence, behaviour optimally advances towards adaptive long-term goals and suppresses conflicting maladaptive short-lived urges to balance impulsivity, exploration and defiance, while establishing effective societal participation. When self-control fails to develop, violence, injury and neurological, mental health and substance-use disorders can result, further challenging the development of self-regulation and impeding the transition to a productive adulthood. Adolescent outcomes, positive and negative, arise from both a life-course perspective and within a socioecological framework. Little is known about the emergence of self-control and regulation in adolescents in low- and middle-income countries where enormous environmental threats are more common (for example, poverty, war, local conflicts, sex trafficking and slavery, early marriage and/or pregnancy, and the absence of adequate access to education) than in high-income countries and can threaten optimal neurodevelopment. Research must develop or adapt appropriate assessments of adolescent ability and disability, social inclusion and exclusion, normative development, and neurological, mental health and substance-use disorders. Socioecological challenges in low- and middle-income countries require innovative strategies to prevent mental health, neurological and substance-use disorders and develop effective interventions for adolescents at risk, especially those already living with these disorders and the consequent disability.

Indexed as

AdolescentBrain InjuriesDeveloping CountriesExposure to ViolenceFemaleHumansIntimate Partner ViolenceMental HealthNeurocognitive DisordersNeurodevelopmental DisordersPregnancyPregnancy in AdolescencePsychological TraumaSubstance-Related DisordersWar Exposure

Identifiers

PMID26580322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.