Observational studyEpilepsy & behavior : E&B2015
Risk factors for reading disability in families with rolandic epilepsy.
Observational study in Epilepsy & behavior : E&B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Neurodevelopmental origins of self-limiting rolandic epilepsy: Systematic review of MR imaging studies.Epilepsia open · 2021Pooled it
- Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children.Medicine · 2017Trial
- Not All Spikes Are Equal.Journal of clinical medicine · 2025Review
- Poor School Academic Performance and Benign Epilepsy with Centro-Temporal Spikes.Behavioral sciences (Basel, Switzerland) · 2023Review
- Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy.Medicine · 2022Article
- Dyscalculia and dyslexia in Chinese children with idiopathic epilepsy: Different patterns of prevalence, comorbidity, and gender differences.Epilepsia open · 2022Article
- Article
- Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set.Trials · 2017Review
- Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes.Epilepsia open · 2017Article
- Maternal Stress and Coping Strategies in Developmental Dyslexia: An Italian Multicenter Study.Frontiers in psychiatry · 2017Article
- A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.Annals of clinical and translational neurology · 2016Article
- 2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across The Lifespan.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
26 authors at 14 institutions in 3 countries.
Funding
Abstract
objectiveThe high prevalence and impact of neurodevelopmental comorbidities in childhood epilepsy are now well known, as are the increased risks and familial aggregation of reading disability (RD) and speech sound disorder (SSD) in rolandic epilepsy (RE). The risk factors for RD in the general population include male sex, SSD, and ADHD, but it is not known if these are the same in RE or whether there is a contributory role of seizure and treatment-related variables.
methodsAn observational study of 108 probands with RE (age range: 3.6-22 years) and their 159 siblings (age range: 1-29 years; 83 with EEG data) were singly ascertained in the US or UK through a proband affected by RE. We used a nested case-control design, multiple logistic regression, and generalized estimating equations to test the hypothesis of an association between RD and seizure variables or antiepileptic drug treatment in RE; we also assessed an association between EEG focal sharp waves and RD in siblings.
resultsReading disability was reported in 42% of probands and 22% of siblings. Among probands, RD was strongly associated with a history of SSD (OR: 9.64, 95% CI: 2.45-37.21), ADHD symptoms (OR: 10.31, 95% CI: 2.15-49.44), and male sex (OR: 3.62, 95% CI: 1.11-11.75) but not with seizure or treatment variables. Among siblings, RD was independently associated only with SSD (OR: 4.30, 95% CI: 1.42-13.0) and not with the presence of interictal EEG focal sharp waves. SIGNIFICANCE: The principal risk factors for RD in RE are SSD, ADHD, and male sex, the same risk factors as for RD without epilepsy. Seizure or treatment variables do not appear to be important risk factors for RD in probands with RE, and there was no evidence to support interictal EEG focal sharp waves as a risk factor for RD in siblings. Future studies should focus on the precise neuropsychological characterization of RD in families with RE and on the effectiveness of standard oral-language and reading interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.