Evidence map›Paper›PMID 26580067›Full record

ArticlePloS one2015

Association between Serum Alkaline Phosphatase Level and Cerebral Small Vessel Disease.

Han-Bin Lee, Jinkwon Kim, Sang-Heum Kim, Soonhag Kim, Ok-Joon Kim, Seung-Hun Oh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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  16. Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Han-Bin LeeDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Jinkwon KimDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Sang-Heum KimDepartment of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Soonhag KimInstitute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, South Korea.
Ok-Joon KimDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Seung-Hun OhDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
CHA University Bundang Medical Center · KRCatholic Kwandong University International St. Mary's Hospital · KRCHA University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum alkaline phosphatase (ALP) is a marker of vascular calcification. A high serum ALP level is associated with an increase in cardiovascular events, and predicts poor functional outcome in patients with stroke. We investigated whether serum ALP was associated with cerebral small vessel disease (cSVD) and large cerebral artery stenosis (LCAS).

methodsWe evaluated vascular risk factors, brain magnetic resonance images (MRIs), and MR angiograms from 1,011 neurologically healthy participants. The presence of silent lacunar infarction (SLI) and moderate-to-severe cerebral white matter hyperintensities (MS-cWMH) were evaluated as indices of cSVD on brain MRIs. Findings of extracranial arterial stenosis (ECAS) or intracranial arterial stenosis (ICAS) were considered to be indices of LCAS on MR angiograms.

resultsSubjects with SLI (odds ratio [OR]: 2.09; 95% confidence interval [CI]: 1.27-3.42; p = 0.004) and MS-cWMH (OR: 1.48; 95% CI; 1.03-2.13, p = 0.036) were significantly more likely to have ALP levels in the third tertile (ALP ≥ 195 IU/L) than the first tertile (ALP ≤ 155 IU/L), after adjusting for cardiovascular risk factors. The mean serum ALP level was significantly higher in patients with SLI or MS-cWMH compared to patients without those findings. After adjustment for confounding factors, the multivariate model found that the statistical significance of serum ALP remained when the presence of SLI (OR: 1.05 per 10 IU/L increase in ALP; 95% CI: 1.02-1.08; p = 0.003) or MS-cWMH (OR: 1.03 per 10 IU/L increase in ALP; 95% CI: 1.00-1.06; p = 0.025) were added to the model. There were no differences in the proportions of patients with LCAS, ICAS, and ECAS across the serum ALP tertiles.

conclusionsOur study of neurologically healthy participants found a positive association between serum ALP level and indicators of cSVD, but no association between serum ALP level and the indicators of LCAS.

Indexed as

AgedAlkaline PhosphataseCardiovascular DiseasesCerebral Small Vessel DiseasesFemaleHumansLogistic ModelsMaleMiddle AgedRisk FactorsStrokeStroke, LacunarAlkaline Phosphatase

Identifiers

PMID26580067
PMCPMC4651565
OpenAlexW2172459401

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.