ArticleNature2015
Sweet and bitter taste in the brain of awake behaving animals.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 249 citations in OpenAlex.
- Trial
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- In praise of the hyperbola.Journal of the experimental analysis of behavior · 2026Review
- Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness "Liking".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A brain stem circuit integrating reflexive and anticipatory salivation.Cell reports · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gustatory thalamic neurons mediate aversive behaviors.Nature communications · 2025Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Article
- Genome-wide association analysis revealed novel candidate genes for body measurement traits in indigenous Gudali and crossbred Simgud in Cameroon.BMC genomics · 2025Article
- Exogenous oral application of PYY and exendin-4 impacts upon taste-related behavior and taste perception in wild-type mice.Neuropharmacology · 2025Article
- A top-down insular cortex circuit crucial for non-nociceptive fear learning.Science advances · 2025Article
- Neuroaesthetics: exploring the role of aesthetic experience in neurorehabilitation.Frontiers in psychology · 2025Article
- Metabolomics analysis reveals the bitter active ingredients inFrontiers in nutrition · 2025Article
- How does bitterness perception correlate with the intention to use traditional Chinese medicine? An analysis of double-edged sword effects based on the stimuli-organism-response framework.Frontiers in public health · 2025Article
- The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.Neuroscience bulletin · 2024Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Taste is responsible for evaluating the nutritious content of food, guiding essential appetitive behaviours, preventing the ingestion of toxic substances, and helping to ensure the maintenance of a healthy diet. Sweet and bitter are two of the most salient sensory percepts for humans and other animals; sweet taste allows the identification of energy-rich nutrients whereas bitter warns against the intake of potentially noxious chemicals. In mammals, information from taste receptor cells in the tongue is transmitted through multiple neural stations to the primary gustatory cortex in the brain. Recent imaging studies have shown that sweet and bitter are represented in the primary gustatory cortex by neurons organized in a spatial map, with each taste quality encoded by distinct cortical fields. Here we demonstrate that by manipulating the brain fields representing sweet and bitter taste we directly control an animal's internal representation, sensory perception, and behavioural actions. These results substantiate the segregation of taste qualities in the cortex, expose the innate nature of appetitive and aversive taste responses, and illustrate the ability of gustatory cortex to recapitulate complex behaviours in the absence of sensory input.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.