Evidence map›Paper›PMID 26579733›Full record

ArticleRadiology2016

Radiomics: Images Are More than Pictures, They Are Data.

Robert J Gillies, Paul E Kinahan, Hedvig Hricak

12 registry-linked trialsAbstract read
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 12 registered trials, which are not on this map. Cited by 4,885 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4,885citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03138915 nacompletednot on this mapstarted 2017, after this paper: background citation

Development and Validation of a Radiomics Signature for Clinically Significant Portal Hypertension in Cirrhosis (CHESS1701): a Prospective Multicenter Study

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2017 to 2017Enrolled385ConditionsHypertension, PortalArmsHVPG measurement, CTA
NCT03198975 unknown statusnot on this mapstarted 2017, after this paper: background citation

Development of a Machine Learning-based Model for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma

TypeobservationalSponsorMing KuangRan2017 to 2017Enrolled40ConditionsHepatocellular CarcinomaArmsMagnetic resonance image
NCT03373123 nawithdrawnnot on this mapstarted 2017, after this paper: background citation

Radiomics-based Surrogate of Endoscopy (rEndosc) for Noninvasive Prediction of Esophageal Varices and Risk Stratification of Variceal Hemorrhage in Hepatitis B Virus-related Cirrhosis (CHESS1703)

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2017 to 2018Enrolled0ConditionsEsophageal Varices in Cirrhosis of the LiverArmsEndoscopy, CTA
NCT03488446 unknown statusnot on this mapstarted 2017, after this paper: background citation

Radiomics for Prediction of Lymph Node Metastasis in Gastric Cancer(RPLNM)(GIPMCS-1701)

TypeobservationalSponsorNanfang Hospital, Southern Medical UniversityRan2017 to 2019Enrolled500ConditionsDigestive System Diseases, Gastrointestinal Neoplasms, Digestive System Neoplasms, Gastrointestinal Diseases
NCT03766880 nacompletednot on this mapstarted 2018, after this paper: background citation

MR-based Models for Noninvasive Detection of Clinically Significant Portal Hypertension in Cirrhosis (CHESS1802)

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2018 to 2019Enrolled175ConditionsHypertension, PortalArmsTransjugular HVPG measurement, MR imaging
NCT05254132 unknown statusnot on this mapstarted 2022, after this paper: background citation

Artificial Intelligence to Help Non-Small Cell Lung Cancer Patients: Measure Lung Cancer Biology and Treatment Response Via Imaging

TypeobservationalSponsorOncoRadiomicsRan2022 to 2025Enrolled1,000ConditionsNon Small Cell Lung CancerArmsLiquid biopsy
NCT05331040 withdrawnnot on this mapstarted 2020, after this paper: background citation

The New Challenge of Decoding Rectal Cancer Signatures By Non-Invasive Imaging: A Retrospective Radiomics Study

TypeobservationalSponsorNHS GrampianRan2020 to 2021Enrolled0ConditionsRectal CancerArmsMRI
NCT05466760 unknown statusnot on this mapstarted 2018, after this paper: background citation

Use of PET/MR Radiomics to Evaluate the Clinical Phenotypes, Response Status of Neoadjuvant Chemotherapy and Long-term Prognosis of Breast Cancer: a Preliminary Study

Typeobservational_patient_registrySponsorTaipei Veterans General Hospital, TaiwanRan2018 to 2022Enrolled120ConditionsBreast CancerArmsPET/MR
NCT05739500 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Clinical Trial 01 to Evaluate the Effectiveness of MRI-based Computer Aided Diagnosis Software (V1) for Glioma Segmentation, Gene Prediction and Tumor Grading

TypeobservationalSponsorMingge LLCRan2022 to 2025Enrolled250ConditionsGlioma, Primary Brain Tumor
NCT06108310 unknown statusnot on this mapstarted 2021, after this paper: background citation

ATTRACT - ArTificial inTelligence-based RAdiogenomics in Colon Tumors

TypeobservationalSponsorUniversity of Roma La SapienzaRan2021 to 2025Enrolled500ConditionsColon Cancer Stage II, Colon Cancer Stage III
NCT06144762 narecruitingnot on this mapstarted 2023, after this paper: background citation

Precision Imaging for Early Detection and Targeted Treatment Monitoring in Pancreatic Cancer

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2023 to 2029Enrolled150ConditionsPancreas CancerArmsBiological/Vaccine: Blood sample and tissue sample
NCT06405815 completednot on this mapstarted 2021, after this paper: background citation

Development of a Tumor and Peritumor Radiomics-based Model to Predict the High-risk Surgical Margin and Prognosis of T3 and T4 Non-Small Cell Lung Cancer

TypeobservationalSponsorJinling Hospital, ChinaRan2021 to 2023Enrolled200ConditionsLung Cancer, Nonsmall CellArmstumor and peritumor radiomic feature
3 · Its place in the literature

Who cites it

4,885 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  3. PET-CT radiomics and artificial intelligence for predicting lymph node metastasis in cervical cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4,825 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert J GilliesFrom the Department of Cancer Imaging, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612 (R.J.G.); Department of Radiology, University of Washington, Seattle, Wash (P.E.K.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York NY 10065 (H.H.).
Paul E KinahanFrom the Department of Cancer Imaging, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612 (R.J.G.); Department of Radiology, University of Washington, Seattle, Wash (P.E.K.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York NY 10065 (H.H.).
Hedvig HricakFrom the Department of Cancer Imaging, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612 (R.J.G.); Department of Radiology, University of Washington, Seattle, Wash (P.E.K.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York NY 10065 (H.H.).

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Physi(ologi)cal Microenvironment and its Role in Tumor Invasion and MetastaseU54CA143970 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GATENBY, ROBERT A · 2009 to 2014
$9.3M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
(PQC4) Habitats in Prostate CancerR01CA190105 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BALAGURUNATHAN, YOGANAND, GILLIES, ROBERT J. · 2014 to 2017
$2.8M
Imaging Habitats in SarcomaR01CA187532 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., MARTINEZ, GARY · 2015 to 2019
$2.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA187532NCI NIH HHS R01CA187532NCI NIH HHS R01 CA190105NCI NIH HHS R01CA190105NCI NIH HHS U01 CA143062NCI NIH HHS U01CA143062NCI NIH HHS U54 CA143970NCI NIH HHS U54CA143970
6 · The paper itself

Abstract

In the past decade, the field of medical image analysis has grown exponentially, with an increased number of pattern recognition tools and an increase in data set sizes. These advances have facilitated the development of processes for high-throughput extraction of quantitative features that result in the conversion of images into mineable data and the subsequent analysis of these data for decision support; this practice is termed radiomics. This is in contrast to the traditional practice of treating medical images as pictures intended solely for visual interpretation. Radiomic data contain first-, second-, and higher-order statistics. These data are combined with other patient data and are mined with sophisticated bioinformatics tools to develop models that may potentially improve diagnostic, prognostic, and predictive accuracy. Because radiomics analyses are intended to be conducted with standard of care images, it is conceivable that conversion of digital images to mineable data will eventually become routine practice. This report describes the process of radiomics, its challenges, and its potential power to facilitate better clinical decision making, particularly in the care of patients with cancer.

Indexed as

Diagnostic ImagingMedical InformaticsAlgorithmsBiopsyData MiningDecision MakingDiagnosis, Computer-AssistedGenomicsHumansImage Interpretation, Computer-AssistedNeoplasmsPrognosisRadiology Information Systems

Identifiers

PMID26579733
PMCPMC4734157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 6 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.