Evidence map›Paper›PMID 26579618›Full record

ArticleJournal of cellular biochemistry2016

Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone.

Saja A Al-Dujaili, Amy J Koh, Ming Dang, Xue Mi, Wenhan Chang, Peter X Ma, Laurie K McCauley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  13. Anabolic actions of PTH in murine models: two decades of insights.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
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  18. Observational
  19. [Effects of calcium ion on the migration and osteogenic differentiation of human osteoblasts].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Saja A Al-DujailiDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan.
Amy J KohDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan.
Ming DangMacromolecular Science and Engineering Center, University of Michigan, Ann Arbor, Michigan.
Xue MiMacromolecular Science and Engineering Center, University of Michigan, Ann Arbor, Michigan.
Wenhan ChangEndocrine Research Unit, University of California, San Francisco, California.
Peter X MaMacromolecular Science and Engineering Center, University of Michigan, Ann Arbor, Michigan.
Laurie K McCauleyDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USUniversity of California, San Francisco · US

Funding

Small Animal Imaging CoreP50CA093990 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUSSAIN, MAHA H · 2002 to 2012
$19.0M
ANABOLIC MECHANISMS OF PTH ACTION IN BONER01DK053904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 1998 to 2016
$4.6M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
Combined PTH and Calcimimetic Therapy and Its Mechanisms for OsteoanabolismR01AR067291 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN · 2015 to 2019
$1.7M
The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain InjuryI01BX001960 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI CHANG, WENHAN · 2013 to 2016
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BLRD VA I01 BX001960NCI NIH HHS P50 CA093990NIAMS NIH HHS R01 AR067291NIDCR NIH HHS R01 DE022327NIDDK NIH HHS R01 DK053904
6 · The paper itself

Abstract

Anabolic actions of PTH in bone involve increased deposition of mineralizing matrix. Regulatory feedback of the process may be important to maintain calcium homeostasis and, in turn, calcium may inform the process. This investigation clarified the role of calcium availability and the calcium sensing receptor (CaSR) in the anabolic actions of PTH. CaSR function promoted osteoblastic cell numbers, with lower cell numbers in post-confluent cultures of primary calvarial cells from Col1-CaSR knock-out (KO) mice, and for calvarial cells from wild-type (WT) mice treated with a calcilytic. Increased apoptosis of calvarial cells with calcilytic treatment suggested CaSR is critical for protection against stage-dependent cell death. Whole and cortical, but not trabecular, bone parameters were significantly lower in Col1-CaSR KO mice versus WT littermates. Intact Col1-CaSR KO mice had lower serum P1NP levels relative to WT. PTH treatment displayed anabolic actions in WT and, to a lesser degree, KO mice, and rescued the lower P1NP levels in KO mice. Furthermore, PTH effects on whole tibiae were inhibited by osteoblast-specific CaSR ablation. Vertebral body implants (vossicles) from untreated Col1-CaSR KO and WT mice had similar bone volumes after 4 weeks of implantation in athymic mice. These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH anabolic effects on bone. J. Cell. Biochem. 117: 1556-1567, 2016. © 2015 Wiley Periodicals, Inc.

Indexed as

AnimalsCalciumCell SurvivalMiceMice, KnockoutMice, NudeOsteoclastsOsteogenesisParathyroid HormonePeptide FragmentsProcollagenReceptors, Calcium-SensingReceptors, G-Protein-CoupledSkullCalciumCASR protein, mouseParathyroid HormonePeptide FragmentsProcollagenprocollagen Type I N-terminal peptideReceptors, Calcium-SensingReceptors, G-Protein-CoupledCALCIUMCALCIUM SENSING RECEPTOROSTEOBLASTSPARATHYROID HORMONE

Identifiers

PMID26579618
PMCPMC4856537
OpenAlexW2202863616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.