ArticleFrontiers in molecular biosciences2015
A proposal for a dipole-generated BLUF domain mechanism.
Article in Frontiers in molecular biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Direct Observation of Franck-Condon Stimulated Emission and Sub-20 fs Relaxation in Photoexcited Flavins.The journal of physical chemistry letters · 2026Article
- Sensing a rainbow of colors: algal photoreceptors.Frontiers in plant science · 2025Review
- Nanocellulose Composites as Smart Devices With Chassis, Light-Directed DNA Storage, Engineered Electronic Properties, and Chip Integration.Frontiers in bioengineering and biotechnology · 2022Article
- From crystallographic data to the solution structure of photoreceptors: the case of the AppA BLUF domain.Chemical science · 2021Article
- Ultrafast Transient Infrared Spectroscopy of Photoreceptors with Polarizable QM/MM Dynamics.The journal of physical chemistry. B · 2021Article
- Formation of an unusual glutamine tautomer in a blue light using flavin photocycle characterizes the light-adapted state.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structural Basis for the Regulation of Biofilm Formation and Iron Uptake inACS infectious diseases · 2020Article
- Physical methods for studying flavoprotein photoreceptors.Methods in enzymology · 2019Article
- Light-induced chromophore and protein responses and mechanical signal transduction of BLUF proteins.Biophysical reviews · 2018Review
- Role of active site conformational changes in photocycle activation of the AppA BLUF photoreceptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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2 authors.
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Abstract
The resting and signaling structures of the blue-light sensing using flavin (BLUF) photoreceptor domains are still controversially debated due to differences in the molecular models obtained by crystal and NMR structures. Photocycles for the given preferred structural framework have been established, but a unifying picture combining experiment and theory remains elusive. We summarize present work on the AppA BLUF domain from both experiment and theory. We focus on IR and UV/vis spectra, and to what extent theory was able to reproduce experimental data and predict the structural changes upon formation of the signaling state. We find that the experimental observables can be theoretically reproduced employing any structural model, as long as the orientation of the signaling essential Gln63 and its tautomer state are a choice of the modeler. We also observe that few approaches are comparative, e.g., by considering all structures in the same context. Based on recent experimental findings and a few basic calculations, we suggest the possibility for a BLUF activation mechanism that only relies on electron transfer and its effect on the local electrostatics, not requiring an associated proton transfer. In this regard, we investigate the impact of dispersion correction on the interaction energies arising from weakly bound amino acids.
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