Evidence map›Paper›PMID 26579440›Full record

ReviewActa pharmaceutica Sinica. B2015

Emerging role of microRNAs in lipid metabolism.

Zhihong Yang, Tyler Cappello, Li Wang

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 173 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Tuning epigenetics to enhance cancer virotherapy.Acta pharmaceutica Sinica. B · 2026
    Review
  5. Article
  6. iMeta · 2025
    Article
  7. Review
  8. Non-coding RNAs in alcohol-associated liver disease.Liver research (Beijing, China) · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhihong YangDepartment of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA ; Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA.
Tyler CappelloDepartment of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.
Li WangDepartment of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA ; Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA ; Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.
University of Connecticut · USInstitute for Systems Biology · US

Funding

SHP-regulation of Lipid and Lipoprotein MetabolismR01DK080440 · NIDDK · UNIVERSITY OF UTAH · PI WANG, LI · 2008 to 2015
$2.3M
Molecular Basis of Cancer Cell Metabolic ReprogrammingR01ES025909 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2017
$1.0M
Alcohol, nuclear receptor signaling, and circadian clocksR21AA022482 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2016
$415k
Circadian Clock Regulation of Alcoholic Liver DiseaseI01BX002634 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI WANG, LI · 2016 to 2019
–
BLRD VA I01 BX002634NIAAA NIH HHS R21 AA022482NIDDK NIH HHS R01 DK080440NIEHS NIH HHS R01 ES025909
6 · The paper itself

Abstract

microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of miRNAs expression. We emphasized on several representative miRNAs that are functionally involved into lipid metabolism, including miR-33/33(⁎), miR122, miR27a/b, miR378/378(⁎), miR-34a and miR-21. Understanding the function of miRNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease.

Indexed as

ABCA1, adenosine triphosphate-binding cassette transporter A1ABCG1, adenosine triphosphate-binding cassette transporter G1Ago2, argonaute 2AMPKα, AMP-activated protein kinase αApoA1, apolipoprotein A1ATP8B1, aminophospholipid transporter, class I, type 8B, member 1BDL, bile-duct ligationCPT1A, carnitine palmitoyltransferase 1ACRAT, carnitine O-acetyltransferaseCYP26, cytochrome P450 family 26CYP3A4, cytochrome P450 family 3 subfamily A polypeptide 4ERRγ, estrogen-related receptor gammaFABP7, fatty acid-binding protein 7FASN, fatty acid synthaseFGF21, fibroblast growth factor 21FGFR1, fibroblast growth factor receptor 1FXR, farnesoid X receptorGABPA, GA binding protein transcription factor alpha subunitGPC6, glypican 6HADHB, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase trifunctional protein, beta subunitHCC, hepatocellular carcinomaHCV, hepatitis C virusHMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCS1, 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1HNE, 4-hydroxynonenalIGF1R, insulin-like growth factor 1 receptorIGFBP3, insulin-like growth factor binding protein 3INSIG1, insulin induced gene 1LIPE, lipase hormone-sensitiveLipid metabolismLNA, locked nucleic acidsLNPs, lipid-based nanoparticlesLPS, lipopolysaccharideMED13, mediator complex subunit 13MHV68, murine γ-herpesvirus 68microRNAsmiRNAs or miRs, microRNAsMTTP, microsomal TG transfer proteinNR1D1/REV-ERBα, transcriptional repressor nuclear receptor subfamily 1 group D member 1NRs, nuclear receptorsNuclear receptorsPCK1, phosphoenolpyruvate carboxykinase 1PDCD4, programmed cell death 4PGC-1, peroxisone proliferator-activated receptor gamma coactivatorPLIN1, perilipin 1PNA, peptide nucleic acidPNPLA2, patatin-like phospholipase domain containing 2PPARγ, peroxisone proliferator-activated receptor gammapre-miRNAs, precursor-miRNAspri-miRNAs, primary-miRNAsRTL1, retrotransposon-like 1RXRα, retinoid X receptor alphaSHP, small heterodimer partnerSIRT1, sirtuin 1SIRT6, sirtuin 6TG, triglycerideTLR4, toll-like receptor 4

Identifiers

PMID26579440
PMCPMC4629215
OpenAlexW2056577175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.