Evidence map›Paper›PMID 26579437›Full record

ReviewActa pharmaceutica Sinica. B2015

Bile acid signaling and biliary functions.

Hannah Jones, Gianfranco Alpini, Heather Francis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B.Journal of clinical and translational hepatology · 2026
    Review
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Organoids in biliary atresia.World journal of pediatric surgery · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. FXR Friend-ChIPs in the Enterohepatic System.Seminars in liver disease · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hannah JonesBaylor Scott & White Digestive Disease Research Center, Temple, TX 76504, USA.
Gianfranco AlpiniDivision Research, Central Texas Veterans Health Care System, Temple, TX 76504, USA ; Baylor Scott & White Digestive Disease Research Center, Temple, TX 76504, USA ; Department of Medicine, Texas A&M University, Temple, TX 76504, USA.
Heather FrancisDivision Research, Central Texas Veterans Health Care System, Temple, TX 76504, USA ; Baylor Scott & White Digestive Disease Research Center, Temple, TX 76504, USA ; Department of Medicine, Texas A&M University, Temple, TX 76504, USA.

Funding

Histamine modulation of biliary proliferation and damageIK2BX001760 · VA · OLIN TEAGUE VETERANS CENTER · PI FRANCIS, HEATHER L · 2013 to 2015
–
BLRD VA IK2 BX001760
6 · The paper itself

Abstract

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5-7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.

Indexed as

ABCB4, ATP-binding cassette, sub-family BAE2, anion exchanger 2AKT, protein kinases BASBT, apical sodium bile acid transporterBA, bile acidBASIC, bile acid sensitive ion channelBile acidsCa2+, intracellular calciumCholangiocytesCl−/HCO3−, chloride bicarbonate exchangerCOX-2, cyclooxygenase-2CYP27, sterol-27-hydroxylaseCYP7A1, cholesterol 7α-hydroxylaseEGFR, epidermal growth factor receptorERK, extracellular regulated protein kinasesFGF, fibroblast growth factorFXR, farnesoid X receptorHGF, hepatocyte growth factorIL-6, interleukin-6MAPK, mitogen-activated protein kinaseOST, organic solute transporterPBC, primary biliary cirrhosisPC-1, polycystin-1PM, plasma membranePSC, primary sclerosing cholangitisReceptorsS1PR2, sphingosine 1-phosphate receptor 2S1P, sphingosine-1-phosphateSignalingSR, secretin receptorTCA, taurocholic acidTGR5, transmembrane G protein coupled receptorUDCA, ursodeoxycholic acid

Identifiers

PMID26579437
PMCPMC4629225

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.