Evidence map›Paper›PMID 26579420›Full record

ReviewActa pharmaceutica Sinica. B2015

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage.

Kai Sun, Jingyu Fan, Jingyan Han

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 2 pooled it
31.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 2 syntheses or guidelines pooled it, 252 citations in OpenAlex.

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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kai SunTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China ; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China ; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Beijing Institute of Integration of Chinese and Western Medicine for Microangiopathy, Beijing 100191, China.
Jingyu FanTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China ; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Beijing Institute of Integration of Chinese and Western Medicine for Microangiopathy, Beijing 100191, China.
Jingyan HanTasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China ; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China ; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine, Beijing 100191, China ; Beijing Institute of Integration of Chinese and Western Medicine for Microangiopathy, Beijing 100191, China.
State Administration of Traditional Chinese Medicine of the People's Republic of China · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.

Indexed as

8-OHdG, 8-hydroxydeoxyguanosineAIF, apoptosis inducing factorAMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidAntioxidantAP-1, activator protein-1Asp, aspartateBBB, brain blood barrierbFGF, basic fibroblast growth factorBMEC, brain microvascular endothelial cellBNDF, brain-derived neurotrophic factorBrain blood barriercAMP, cyclic adenosine monophosphateCAT, catalaseCav-1, caveolin-1CBF, cerebral blood flowCOX-2, cyclooxygenase-2DHR, dihydrorhodamine 123DPPH, 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazylERK, extracellular signal-regulated kinaseGABA, γ-aminobutyric acidGlu, glutamateGly, glysineGRK2, G protein-coupled receptor kinase 2GSH, glutathioneGSH-Px, glutathione peroxidaseGSSH, glutathione disulfideHE, hematoxylin and eosinHIF, hypoxia-inducible factorHPLC, high performance liquid chromatographyhs-CRP, high-sensitivity C-reactive proteinHyperpermeabilityICAM-1, intercellular adhesion molecule-1IL-10, interleukin-10IL-1β, interleukin-1βIL-8, interleukin-8iNOS, inducible nitric oxide synthaseI/R, ischemia-reperfusionIschemia/reperfusionI-κBα, Inhibitory κBαJAM-1, junctional adhesion molecule-1JNK, Jun N-terminal kinaseLDH, lactate dehydrogenaseLeukocyte adhesionMAPK, mitogen activated protein kinaseMCAO, middle cerebral artery occlusionMDA, malondialdehydeMMPs, matrix metalloproteinasesMPO, myeloperoxidaseMRI, magnetic resonance imagingNADPH, nicotinamide adenine dinucleotide phosphateNeuronNF-κB, nuclear factor κ-BNGF, nerve growth factorNMDA, N-methyl-d-aspartic acidNO, nitric oxideNSC, neural stem cellsOGD, oxygen-glucose deprivationPARP, poly-ADP-ribose polymerasePMN, polymorphonuclearRANTES, regulated upon activation normal T-cell expressed and secretedROS, reactive oxygen speciesrtPA, recombinant tissue plasminogen activatorSFDA, state food and drug administrationSOD, superoxide dismutaseTBARS, thiobarbituric acid reactive substanceTCM, traditional Chinese medicineTGF-β1, transforming growth factor β1TIMP-1, tissue inhibitor of metalloproteinase-1TNF-α, tissue necrosis factor-αTTC, 2,3,5-triphenyltetrazolium chlorideTuj-1, class III β-tublinTUNEL, terminal-deoxynucleoitidyl transferase mediated nick end labelingVCAM-1, vascular adhesion molecule-1VEGF, vascular endothelial growth factorZO-1, zonula occludens-1

Identifiers

PMID26579420
PMCPMC4629119
OpenAlexW1992891849

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.