Evidence map›Paper›PMID 26579419›Full record

ReviewActa pharmaceutica Sinica. B2015

S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics.

Jun Han, Pengfei Wu, Fang Wang, Jianguo Chen

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Electrophysiological Profile RemodelingFrontiers in cellular neuroscience · 2020
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jun HanDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Pengfei WuDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fang WangDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ; Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China ; Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, Hubei, China ; The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China.
Jianguo ChenDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ; Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China ; Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, Hubei, China ; The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations. S-palmitoylation, an important lipid modification by post-translational addition of a long-chain fatty acid to a cysteine residue, regulates AMPA receptor trafficking, which dynamically affects multiple fundamental brain functions, such as learning and memory. In vivo, S-palmitoylation is controlled by palmitoyl acyl transferases and palmitoyl thioesterases. In this review, we highlight advances in the mechanisms for dynamic AMPA receptors palmitoylation, and discuss how palmitoylation affects AMPA receptors function at synapses in recent years. Pharmacological regulation of S-palmitoylation may serve as a novel therapeutic strategy for neurobiological diseases.

Indexed as

17-ODYA, 17-octadecynoic acidABE, acyl-biotinyl exchangeABP, AMPA receptor binding proteinAD, Alzheimer׳s diseaseAKAP79/150, A-kinase anchoring protein 79/150AMPA receptorsAMPAR, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptorAPT1, acyl-protein thioesterase-1APT2, acyl-protein thioesterase-2CP-AMPARs, Ca2+-permeable AMPARsDHHCDHHC, aspartate-histidine-histidine-cysteineFMRP, fragile X mental retardation proteinFXS, Fragile X syndromeGAP-43, growth associated protein-43GRIP, glutamate receptor interacting proteinLTD, long-term depressionLTP, long-term potentiationPalmitoylationPATs, palmitoyl acyl transferasesPDZ, postsynaptic density-95/discs large/zona occludens-1PICK1, protein interacting with C-kinase 1PKA, protein kinase APKC, protein kinase CPPT1, palmitoyl-protein thioesterase-1PSD-95, postsynaptic density-95Ras, rat sarcomaSNAP-23, soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor protein-23Trafficking

Identifiers

PMID26579419
PMCPMC4629138
OpenAlexW1976598676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.