ArticleActa pharmaceutica Sinica. B2014
Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents.
Article in Acta pharmaceutica Sinica. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon responseJournal of veterinary research · 2024Article
- Medicinal chemistry strategies toward host targeting antiviral agents.Medicinal research reviews · 2020Review
- Synthesis, characterization and in vitro biological evaluation of two matrine derivatives.Scientific reports · 2018Article
- Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents.Acta pharmaceutica Sinica. B · 2018Article
- Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents.Chemistry Central journal · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hepatitis C virus (HCV) infection has become a major public health burden worldwide. Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro. The structure-activity analysis revealed that (i) sophocarpinic acids with a D-seco 3-ring structure scaffold were more favorable than matrines with a 4-ring scaffold; (ii) the introduction of an electron-withdrawing group on the phenyl ring in 12-N-benzenesulfonyl Δ (βγ) sophocarpinic acids was beneficial for the antiviral activity against HCV. Among them, compounds 9h and 9j exhibited the most potent inhibitory activities on HCV replication with selectivity indies of 70.3 and 30.9, respectively. Therefore, both were selected as antiviral candidates for further investigation.
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