Evidence map›Paper›PMID 26579381›Full record

ReviewActa pharmaceutica Sinica. B2014

Nutraceuticals as potential therapeutic agents for colon cancer: a review.

Palaniselvam Kuppusamy, Mashitah M Yusoff, Gaanty Pragas Maniam, Solachuddin Jauhari Arief Ichwan, Ilavenil Soundharrajan, Natanamurugaraj Govindan

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 122 citations in OpenAlex.

  1. USP10-mediated deubiquitination and activation ofActa pharmaceutica Sinica. B · 2026
    Article
  2. Review
  3. Pharmaceuticals (Basel, Switzerland) · 2025
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  7. Review
  8. Article
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  12. Article
  13. Review
  14. Review
  15. Synbiotic microencapsulation ofJournal of food science and technology · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Palaniselvam KuppusamyMammalian Cell Technology Laboratory, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Gambang, Kuantan, Pahang, Malaysia.
Mashitah M YusoffMammalian Cell Technology Laboratory, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Gambang, Kuantan, Pahang, Malaysia.
Gaanty Pragas ManiamMammalian Cell Technology Laboratory, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Gambang, Kuantan, Pahang, Malaysia.
Solachuddin Jauhari Arief IchwanKulliyyah of Dentistry, International Islamic University Malaysia, Bandar Indera Mahkota 25200, Kuantan, Pahang, Malaysia.
Ilavenil SoundharrajanDepartment of Biochemistry, National Institute of Animal Science, Suwon-si, Gyeonggi-do 441706, South Korea.
Natanamurugaraj GovindanMammalian Cell Technology Laboratory, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Gambang, Kuantan, Pahang, Malaysia.
Universiti Malaysia Pahang Al-Sultan Abdullah · MYInternational Islamic University Malaysia · MYNational Institute of Animal Science · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon cancer is a world-wide health problem and the second-most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel and environmentally benign drug therapies for colon cancer. Currently, nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer, diabetes and Alzheimer׳s disease. Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits. Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression. These dietary substances target different molecular aspects of colon cancer development. Accordingly, this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis.

Indexed as

5-FU, 5-fluorouracilACC, acetyl CoA carboxylaseACF, aberrant crypt fociACL, ATP-citrate lyaseASTX, astaxanthinColon cancerCOX-2, cyclooxygenase 2DHA, decahexaenoic acidDMH, 1,2-dimethylhydrazineDR, death receptorEGCG, epigallocatechingallateEPA, eicosapentaenoic acidFAS, fatty acid synthaseGADD, growth arrest and DNA damageHMG-CoA, 3-hydroxy-3-methyl-glutaryl CoAHUVEC, human umbilical vein endothelial cellIGF, insulin-like growth factorIL, interleukinLDH, lactate dehydrogenaseMarine organismsMMP, matrix metallo-proteinsNF-κB, nuclear factor-kappa BNutraceuticalsPlant derivativesPRAP, prolactin receptor associated proteinTCA, tricarboxylic acid cycleTherapeuticsTNF, tumor necrosis factorTRAIL, tumor necrosis factor-related apoptosis-induced ligandVEGF, vascular endothelial growth factor

Identifiers

PMID26579381
PMCPMC4629076
OpenAlexW2141083328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.