ArticleActa pharmaceutica Sinica. B2014
Three-dimensional DEM-CFD analysis of air-flow-induced detachment of API particles from carrier particles in dry powder inhalers.
Article in Acta pharmaceutica Sinica. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 39 citations in OpenAlex.
- Preparation and Study of Erythromycin Dry Powder Inhaler Based on Ternary Complex Structure.AAPS PharmSciTech · 2025Article
- Effects of dose loading conditions and device geometry on the transport and aerosolization in dry powder inhalers: A simulation study.International journal of pharmaceutics · 2021Article
- Particle-based coarse-grained approach for simulating dry powder inhaler.International journal of pharmaceutics · 2021Article
- Flow and Particle Modelling of Dry Powder Inhalers: Methodologies, Recent Development and Emerging Applications.Pharmaceutics · 2021Review
- Novel approach for real-time monitoring of carrier-based DPIs delivery processActa pharmaceutica Sinica. B · 2020Article
- Optimizing Aerosolization Using Computational Fluid Dynamics in a Pediatric Air-Jet Dry Powder Inhaler.AAPS PharmSciTech · 2019Article
- Influence of physical properties of carrier on the performance of dry powder inhalers.Acta pharmaceutica Sinica. B · 2016Review
- Multi-scale modelling of powder dispersion in a carrier-based inhalation system.Pharmaceutical research · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Air flow and particle-particle/wall impacts are considered as two primary dispersion mechanisms for dry powder inhalers (DPIs). Hence, an understanding of these mechanisms is critical for the development of DPIs. In this study, a coupled DEM-CFD (discrete element method-computational fluid dynamics) is employed to investigate the influence of air flow on the dispersion performance of the carrier-based DPI formulations. A carrier-based agglomerate is initially formed and then dispersed in a uniformed air flow. It is found that air flow can drag API particles away from the carrier and those in the downstream air flow regions are prone to be dispersed. Furthermore, the influence of the air velocity and work of adhesion are also examined. It is shown that the dispersion number (i.e., the number of API particles detached from the carrier) increases with increasing air velocity, and decreases with increasing the work of adhesion, indicating that the DPI performance is controlled by the balance of the removal and adhesive forces. It is also shown that the cumulative Weibull distribution function can be used to describe the DPI performance, which is governed by the ratio of the fluid drag force to the pull-off force.
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