ArticleFrontiers in plant science2015
Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of cyclotide-producing plants on the development and life history parameters of Leipothrix violarius.Experimental & applied acarology · 2025Article
- Plant Defense Peptides: Exploring the Structure-Function Correlation for Potential Applications in Drug Design and Therapeutics.ACS omega · 2025Review
- Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Plants (Basel, Switzerland) · 2025Article
- Molecular Chimera in Cancer Drug Discovery: Beyond Antibody Therapy, Designing Grafted Stable Peptides Targeting Cancer.International journal of peptide research and therapeutics · 2025Review
- Harnessing Antiviral Peptides: From Molecular Mechanisms to Clinical Translation.Current research in pharmacology and drug discovery · 2025Review
- Characterization of cyclotides Mra30 and cycloviolacin O17 derived from Viola dalatensis Gadnep.Archives of microbiology · 2024Article
- The involvement of cyclotides in the heavy metal tolerance of Viola spp.Scientific reports · 2024Article
- Plant proteins, peptides, and non-protein amino acids: Toxicity, sources, and analysis.Heliyon · 2024Review
- New Insights into Involvement of Low Molecular Weight Proteins in Complex Defense Mechanisms in Higher Plants.International journal of molecular sciences · 2024Review
- High-throughput microfluidic chip with silica gel-C18 channels for cyclotide separation.Analytical and bioanalytical chemistry · 2023Article
- The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production inPlants (Basel, Switzerland) · 2022Article
- The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite.Scientific reports · 2022Article
- Article
- LC-MS/MS identification and structural characterization of isolated cyclotides from precursor sequences ofJournal of biosciences · 2022Article
- Cyclotide host-defense tailored for species and environments in violets from the Canary Islands.Scientific reports · 2021Article
- Isolation and characterization of cyclotides from the leaves of3 Biotech · 2021Article
- Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase.Frontiers in pharmacology · 2021Article
- The life cycle of cyclotides: biosynthesis and turnover in plant cells.Plant cell reports · 2020Article
- Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions.Journal of the American Society for Mass Spectrometry · 2020Article
- Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decade there has been increasing interest in small circular proteins found in plants of the violet family (Violaceae). These so-called cyclotides consist of a circular chain of approximately 30 amino acids, including six cysteines forming three disulfide bonds, arranged in a cyclic cystine knot (CCK) motif. In this study we map the occurrence and distribution of cyclotides throughout the Violaceae. Plant material was obtained from herbarium sheets containing samples up to 200 years of age. Even the oldest specimens contained cyclotides in the preserved leaves, with no degradation products observable, confirming their place as one of the most stable proteins in nature. Over 200 samples covering 17 of the 23-31 genera in Violaceae were analyzed, and cyclotides were positively identified in 150 species. Each species contained a unique set of between one and 25 cyclotides, with many exclusive to individual plant species. We estimate the number of different cyclotides in the Violaceae to be 5000-25,000, and propose that cyclotides are ubiquitous among all Violaceae species. Twelve new cyclotides from six phylogenetically dispersed genera were sequenced. Furthermore, the first glycosylated derivatives of cyclotides were identified and characterized, further increasing the diversity and complexity of this unique protein family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.