ReviewFrontiers in microbiology2015
Wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of Wolbachia-host interactions.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 146 citations in OpenAlex.
- Pervasive effects ofbioRxiv : the preprint server for biology · 2026Article
- Is the developmental stage important for the plasticity of transgenerational immune priming?Biology open · 2026Article
- Non-Canonical, Somatic-Dependent Vertical Transmission of Wolbachia in an Aphid.Environmental microbiology reports · 2026Article
- Pharmacological Effects of NADPH Oxidase Inhibitors on Butterfly Wing Morphogenesis and Color Pattern Formation inInsects · 2026Article
- The adaptive nature of the foam proteome produced by Mahanarva spectabilis (Hemiptera: Cercopidae) when infesting forage grasses with different levels of antibiosis-type resistance.Scientific reports · 2026Article
- Stress in dipteran insects mass-reared for sterile insect technique applications.Insect science · 2025Review
- The intracellular symbiont Wolbachia alters Drosophila development and metabolism to buffer against nutritional stress.PLoS genetics · 2025Article
- Article
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- Potential effect ofFrontiers in microbiology · 2025Article
- Understanding the role of trehalose in interactions betweenFrontiers in cellular and infection microbiology · 2025Review
- Antioxidants, oxidative stress and reactive oxygen species in insects exposed to heat.Current research in insect science · 2025Review
- Vector competence of Culex quinquefasciatus from Santiago Island, Cape Verde, to West Nile Virus: exploring the potential effect of the vector native Wolbachia.Parasites & vectors · 2024Article
- A comprehensive analysis of the defense responses of Odontotermes formosanus (Shiraki) provides insights into the changes during Serratia marcescens infection.BMC genomics · 2024Article
- Generating prophylactic immunity against arboviruses in vertebrates and invertebrates.Nature reviews. Immunology · 2024Review
- Gut Microbial Diversity Reveals Differences in Pathogenicity betweenMicroorganisms · 2024Article
- Keap1 Negatively Regulates Transcription of Three Counter-Defense Genes and Susceptibility to Plant Toxin Gossypol inInsects · 2024Article
- No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep.Proceedings. Biological sciences · 2024Article
- Safety Assessment of the Potential Probiotic Bacterium Limosilactobacillus fermentum J23 Using the Mexican Fruit Fly (Anastrepha ludens Loew, Diptera: Tephritidae) as a Novel In Vivo Model.Probiotics and antimicrobial proteins · 2024Article
- Development, feeding, and sex shape the relative quantity of the nutritional obligatory symbiontFrontiers in microbiology · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wolbachia are intracellular bacteria that infect a vast range of arthropod species, making them one of the most prevalent endosymbionts in the world. Wolbachia's stunning evolutionary success is mostly due to their reproductive parasitism but also to mutualistic effects such as increased host fecundity or protection against pathogens. However, the mechanisms underlying Wolbachia phenotypes, both parasitic and mutualistic, are only poorly understood. Moreover, it is unclear how the insect immune system is involved in these phenotypes and why it is not more successful in eliminating the bacteria. Here we argue that reactive oxygen species (ROS) are likely to be key in elucidating these issues. ROS are essential players in the insect immune system, and Wolbachia infection can affect ROS levels in the host. Based on recent findings, we elaborate a hypothesis that considers the different effects of Wolbachia on the oxidative environment in novel vs. native hosts. We propose that newly introduced Wolbachia trigger an immune response and cause oxidative stress, whereas in coevolved symbioses, infection is not associated with oxidative stress, but rather with restored redox homeostasis. Redox homeostasis can be restored in different ways, depending on whether Wolbachia or the host is in charge. This hypothesis offers a mechanistic explanation for several of the observed Wolbachia phenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.