ReviewFrontiers in physiology2015
Malformations of the tooth root in humans.
Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Oral Phenotype of Singleton-Merten Syndrome: A Systematic Review Illustrated With a Case Report.Frontiers in genetics · 2022Pooled it
- Relationship between C-shaped root canal configuration in mandibular second molars and radix entomolaris in mandibular first molars: a CBCT-based study in a Western Chinese population.Clinical oral investigations · 2026Article
- Microstructures and mechanical characteristics of primary teeth affected by regional odontodysplasia.Journal of applied oral science : revista FOB · 2026Article
- Finite Element Analysis of Stress Distribution in Immature Permanent Incisors Following MTA Apexification with Different Coronal Base Materials.Biomimetics (Basel, Switzerland) · 2025Article
- Molar Cervical Root Cross-Sectional Morphology and Diet in Extant Catarrhines.American journal of biological anthropology · 2025Article
- Clinical Efficacy of Clear Aligners in Class II Malocclusion: From Pediatric to Adult Cases-A Narrative Review.Journal of functional biomaterials · 2025Review
- Familial, Nonsyndromic, Generalized Radiculomegaly Affecting Both Dentitions: The First Reported Case.International journal of clinical pediatric dentistry · 2025Article
- Effects of maxillary molar distalization using clear aligners during the mixed dentition and early permanent dentition with 3 types of Class II traction: a three-dimensional finite element analysis.BMC oral health · 2025Article
- Optineurin Cooperates With NRF2 to Regulate Tooth Root Morphogenesis by Controlling Mitochondrial Dynamics and Apoptosis.Cell proliferation · 2025Article
- Effect of clear aligners on distalization of maxillary first molars in mixed dentition and early permanent dentition: a retrospective study.Clinical oral investigations · 2025Article
- Orthodontic Forces Interrupt Root Formation in Immature Teeth: Myth or Fact? A Pilot Study.Turkish journal of orthodontics · 2025Article
- Review
- Clinical and Radiographic Evaluation of Molar Root-Incisor Malformation (MRIM): A Case Series.Case reports in dentistry · 2025Article
- Influence of odontogenic lesions on root development in impacted teeth: a cohort study.Frontiers in oral health · 2025Article
- Morphological observations on the role of HERS cells in cementum development of rabbit molars.Frontiers in bioengineering and biotechnology · 2025Article
- Inherited phosphate and pyrophosphate disorders: New insights and novel therapies changing the oral health landscape.Journal of the American Dental Association (1939) · 2024Review
- Three-dimensional visualization of Hertwig's epithelial root sheath during tooth root development with the miniTESOS tissue clearing method.American journal of translational research · 2024Article
- Effects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.Orthodontics & craniofacial research · 2023Review
- Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny.International journal of oral science · 2023Review
- Prevalence of taurodontism in individuals in Northwest China determined by cone-beam computed tomography images.Heliyon · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The most common root malformations in humans arise from either developmental disorders of the root alone or disorders of radicular development as part of a general tooth dysplasia. The aim of this review is to relate the characteristics of these root malformations to potentially disrupted processes involved in radicular morphogenesis. Radicular morphogenesis proceeds under the control of Hertwig's epithelial root sheath (HERS) which determines the number, length, and shape of the root, induces the formation of radicular dentin, and participates in the development of root cementum. Formation of HERS at the transition from crown to root development appears to be very insensitive to adverse effects, with the result that rootless teeth are extremely rare. In contrast, shortened roots as a consequence of impaired or prematurely halted apical growth of HERS constitute the most prevalent radicular dysplasia which occurs due to trauma and unknown reasons as well as in association with dentin disorders. While odontoblast differentiation inevitably stops when growth of HERS is arrested, it seems to be unaffected even in cases of severe dentin dysplasias such as regional odontodysplasia and dentin dysplasia type I. As a result radicular dentin formation is at least initiated and progresses for a limited time. The only condition affecting cementogenesis is hypophosphatasia which disrupts the formation of acellular cementum through an inhibition of mineralization. A process particularly susceptible to adverse effects appears to be the formation of the furcation in multirooted teeth. Impairment or disruption of this process entails taurodontism, single-rooted posterior teeth, and misshapen furcations. Thus, even though many characteristics of human root malformations can be related to disorders of specific processes involved in radicular morphogenesis, precise inferences as to the pathogenesis of these dysplasias are hampered by the still limited knowledge on root formation.
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