ArticleFrontiers in aging neuroscience2015
Lower Bone Mineral Density in Patients with Parkinson's Disease: A Cross-Sectional Study from Chinese Mainland.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 31 citations in OpenAlex.
- Generalized osteoporosis but not axial osteopenia is associated with cognitive impairment in Parkinson's disease.Annals of medicine · 2026Article
- Orthopedic manifestations, complications, and outcomes for arthroplasty in patients with Parkinson disease.Bulletin of the Hospital for Joint Disease (2013) · 2025Review
- Advances in biomonitoring technologies for women's health.Nature communications · 2025Review
- Association between osteoporosis and mortality in Parkinson's disease with mediating effect of hip fractures: a Korean nationwide population-based study.Frontiers in aging neuroscience · 2025Article
- Osteoporosis in Parkinson's disease and the role of lean body mass: a cross-sectional study in a Brazilian tertiary center.Frontiers in endocrinology · 2024Article
- Vitamin D Status and Parkinson's Disease.Brain sciences · 2022Review
- Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson's disease.Scientific reports · 2021Article
- [Characteristics of geriatric and somatic status in patients with osteoporosis].Problemy endokrinologii · 2021Article
- Article
- Parkinson's disease and osteoporosis: basic and clinical implications.Expert review of endocrinology & metabolism · 2020Review
- The outcome for surgical fixation of distal radial fractures in patients with idiopathic Parkinson's disease: a cohort study.Journal of orthopaedic surgery and research · 2020Article
- Effects of Neurological Disorders on Bone Health.Frontiers in psychology · 2020Review
- Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson's Disease.Parkinson's disease · 2019Article
- Plasma Cystatin C and High-Density Lipoprotein Are Important Biomarkers of Alzheimer's Disease and Vascular Dementia: A Cross-Sectional Study.Frontiers in aging neuroscience · 2017Article
- Hyposmia Is Associated with RBD for PD Patients with Variants ofFrontiers in aging neuroscience · 2017Article
- The Monoamine Brainstem Reticular Formation as a Paradigm for Re-Defining Various Phenotypes of Parkinson's Disease Owing Genetic and Anatomical Specificity.Frontiers in cellular neuroscience · 2017Review
- Accuracy Improvement for Predicting Parkinson's Disease Progression.Scientific reports · 2016Article
- Do Bone Mineral Density, Trabecular Bone Score, and Hip Structural Analysis Differ in Indian Men with Parkinson's Disease? A Case-Control Pilot Study from a Tertiary Center in Southern India.Annals of Indian Academy of NeurologyArticle
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsSignificantly lower BMD in PD compared to healthy subjects in both genders.Less than 35 mg(2)/dl(2) of Ca-P product in >80% of PD patients.Significant correlations between BMD and severity of PD.Lower BMD at H&Y stage III/IV than that at H&Y stage I/II.
objectivesAlthough several lines of evidence have suggested that patients with Parkinson's disease (PD) have a higher risk of osteoporosis and fracture, the association between bone mineral density (BMD) and severity of PD patients is unknown.
methodsWe performed a cross-sectional study of 54 patients with PD and 59 healthy age-matched controls. Multiple clinical scales were used to evaluate the severity of PD, and serum levels of calcium, phosphorus, and homocysteine were measured to determine BMD's association with PD severity.
resultsBMD in PD patients was significantly lower than that in healthy controls. The BMD scores of the spine, femoral neck (FN), and hip were lower in females than in males in the healthy group. In the PD group, BMD in the hip was significantly lower in females compared to males. There was a negative correlation between daily l-DOPA dosage and BMD in the spine and hip in the PD group, while BMD in the spine, neck, and hip was significantly correlated with severity of PD. Besides, we found that among the lumbar spine (LS), FN, and hip, bone loss in the LS was the most severe in PD patients based on the T-scores.
conclusionOur findings support the hypothesis that patients with PD have a higher risk of osteoporosis, and that low BMD in the spine, FN, and hip may indirectly reflect the severity of PD. Our findings have prompted us to pay more attention to osteoporosis in the LS in Chinese PD patients.
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