ReviewFrontiers in human neuroscience2015
Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review.
Review in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03816215 (Volunteering as an Intervention to Reduce Depression Among Adolescents), which is not on this map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Volunteering as an Intervention to Reduce Depression Among Adolescents: Investigating Neurobiological Mechanisms
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Transdiagnostic and disease-specific abnormalities in the default-mode network hubs in psychiatric disorders: A meta-analysis of resting-state functional imaging studies.European psychiatry : the journal of the Association of European Psychiatrists · 2020Pooled it
- Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.Neuroscience and biobehavioral reviews · 2016Pooled it
- Effects of Oral Contraceptive Pills on Brain Networks: A Conceptual Replication and Extension.Human brain mapping · 2025Trial
- Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Trial
- Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy.The American journal of psychiatry · 2023Trial
- Dynamic Resting-State Network Biomarkers of Antidepressant Treatment Response.Biological psychiatry · 2022Trial
- Baseline Functional Connectivity in Resting State Networks Associated with Depression and Remission Status after 16 Weeks of Pharmacotherapy: A CAN-BIND Report.Cerebral cortex (New York, N.Y. : 1991) · 2022Trial
- Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naïve patients with major depressive disorder.Human brain mapping · 2021Trial
- Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder.Molecular psychiatry · 2020Trial
- Connectivity of the Cognitive Control Network During Response Inhibition as a Predictive and Response Biomarker in Major Depression: Evidence From a Randomized Clinical Trial.Biological psychiatry · 2020Trial
- Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents.EBioMedicine · 2017Trial
- Group Joint ICA (gjICA): A Method for Multimodal Fusion of Concurrent EEG and fMRI Data.Human brain mapping · 2026Article
- Brain network dysfunction and treatment-induced network reorganization in major depressive disorder.Brain imaging and behavior · 2026Article
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Turbulent-like Dynamics Predict Treatment Outcome in Major Depressive Disorder.Research square · 2025Article
- Early Brain Functional Connectivity Changes Induced by Antidepressants and Placebo.bioRxiv : the preprint server for biology · 2025Article
- Insights on the cognitive enhancement effect of desvenlafaxine in major depressive disorder.Annals of general psychiatry · 2025Article
- Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Substance Use Disorder (SUD)-A Review and Insights into Possible Mechanisms of Action.Journal of clinical medicine · 2025Review
- The effect of non-invasive transcranial focused ultrasound for depression on the default mode network: an open-label pilot trial.Frontiers in psychiatry · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a mental illness that presents alterations in brain connectivity in the Default Mode Network (DMN), the Affective Network (AN) and other cortical-limbic networks, and the Cognitive Control Network (CCN), among others. In recent years the interest in the possible effect of the different antidepressant treatments on functional connectivity has increased substantially. The goal of this paper is to conduct a systematic review of the studies on the relationship between the treatment of depression and brain connectivity. Nineteen studies were found in a systematic review on this topic. In all of them, there was improvement of the clinical symptoms after antidepressant treatment. In 18 out of the 19 studies, clinical improvement was associated to changes in brain connectivity. It seems that both DMN and the connectivity between cortical and limbic structures consistently changes after antidepressant treatment. However, the current evidence does not allow us to assure that the treatment of depression leads to changes in the CCN. In this regard, some papers report a positive correlation between changes in brain connectivity and improvement of depressive symptomatology, particularly when they measure cortical-limbic connectivity, whereas the changes in DMN do not significantly correlate with clinical improvement. Finally, some papers suggest that changes in connectivity after antidepressant treatment might be partly related to the mechanisms of action of the treatment administered. This effect has been observed in two studies with stimulation treatment (one with rTMS and one with ECT), and in two papers that administered three different pharmacological treatments. Our review allows us to make a series of recommendations that might guide future researchers exploring the effect of anti-depression treatments on brain connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.