ArticleFrontiers in human neuroscience2015
Increased striatal functional connectivity with auditory cortex in tinnitus.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus.Frontiers in human neuroscience · 2020Pooled it
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.Scientific reports · 2020Trial
- Increased basal ganglia volume in older adults with tinnitus.Scientific reports · 2025Article
- Topological features of brain functional networks are reorganized during chronic tinnitus: A graph-theoretical study.The European journal of neuroscience · 2025Article
- Deep Brain Stimulation for Primary Refractory Tinnitus: A Systematic Review.Brain sciences · 2024Review
- Resting-state Networks in Tinnitus : A Scoping Review.Clinical neuroradiology · 2022Article
- Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques.Scientific reports · 2022Article
- Striatal networks for tinnitus treatment targeting.Human brain mapping · 2022Article
- Intrinsic brain activity reorganization contributes to long-term compensation of higher-order hearing abilities in single-sided deafness.Frontiers in neuroscience · 2022Article
- Too Blind to See the Elephant? Why Neuroscientists Ought to Be Interested in Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Neuroplasticity within and between Functional Brain Networks in Mental Training Based on Long-Term Meditation.Brain sciences · 2021Article
- Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery.Scientific reports · 2021Article
- Acupuncture Treatment Decreased Temporal Variability of Dynamic Functional Connectivity in Chronic Tinnitus.Frontiers in neuroscience · 2021Article
- Reduced grey- and white matter volumes due to unilateral hearing loss following treatment for vestibular schwannoma.Heliyon · 2020Article
- Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus.Journal of neurosurgery · 2020Article
- Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss.Human brain mapping · 2020Article
- Corticostriatal functional connectivity of bothersome tinnitus in single-sided deafness.Scientific reports · 2019Article
- Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.Frontiers in neuroscience · 2019Article
- Functional and Structural Brain Plasticity in Adult Onset Single-Sided Deafness.Frontiers in human neuroscience · 2018Article
- Abnormal Resting-State Functional Connectivity of the Anterior Cingulate Cortex in Unilateral Chronic Tinnitus Patients.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is a common auditory perceptual disorder whose neural substrates are under intense debate. One physiologically based model posits the dorsal striatum to play a key role in gating auditory phantoms to perceptual awareness. Here, we directly test this model along with the roles of auditory and auditory-limbic networks in tinnitus non-invasively by comparing resting-state fMRI functional connectivity patterns in chronic tinnitus patients against matched control subjects without hearing loss. We assess resting-state functional connectivity of the caudate dorsal striatum (area LC), caudate head (CH), nucleus accumbens (NA), and primary auditory cortex (A1) to determine patterns of abnormal connectivity. In chronic tinnitus, increases in ipsilateral striatal-auditory cortical connectivity are found consistently only in area LC. Other patterns of increased connectivity are as follows: (1) right striatal area LC, A1, CH, and NA with parietal cortex, (2) left and right CHs with dorsal pre-frontal cortex, (3) NA and A1 with cerebellum, hippocampus, visual and ventral pre-frontal cortex. Those findings provide further support for a striatal gating model of tinnitus, where dysfunctionally permissive area LC enables auditory phantoms to reach perceptual awareness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.