ReviewFrontiers in neuroscience2015
I'll take the low road: the evolutionary underpinnings of visually triggered fear.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 165 citations in OpenAlex.
- An auditory "low road" for threat processing in humans sensitive to fast temporal cues.iScience · 2026Article
- A Direct Auditory Subcortical Route to the Amygdala Associated with Fear in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Neuronal mechanism of innate rapid processing of threating animacy cue in primates: insights from the neuronal responses to snake images.Frontiers in psychology · 2024Review
- Evidence for adaptive myelination of subcortical shortcuts for visual motion perception in healthy adults.Human brain mapping · 2023Article
- Defensive responses: behaviour, the brain and the body.Nature reviews. Neuroscience · 2023Review
- Article
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Statistical Perspective on Functional and Causal Neural Connectomics: A Comparative Study.Frontiers in systems neuroscience · 2022Article
- Stress hormones mediate developmental plasticity in vertebrates with complex life cycles.Neurobiology of stress · 2021Article
- Mapping the neural circuitry of predator fear in the nonhuman primate.Brain structure & function · 2021Article
- The influence of subcortical shortcuts on disordered sensory and cognitive processing.Nature reviews. Neuroscience · 2020Review
- A Prototypical Template for Rapid Face Detection Is Embedded in the Monkey Superior Colliculus.Frontiers in systems neuroscience · 2020Article
- The plus maze and scototaxis test are not valid behavioral assays for anxiety assessment in the South African clawed frog.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Speed dependent descending control of freezing behavior in Drosophila melanogaster.Nature communications · 2018Article
- Emotion and the Cardiovascular System: Postulated Role of Inputs From the Medial Prefrontal Cortex to the Dorsolateral Periaqueductal Gray.Frontiers in neuroscience · 2018Review
- "Low road" to rehabilitation: a perspective on subliminal sensory neuroprosthetics.Neuropsychiatric disease and treatment · 2018Article
- A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The mouse pulvinar nucleus: Organization of the tectorecipient zones.Visual neuroscience · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there is general agreement that the central nucleus of the amygdala (CeA) is critical for triggering the neuroendocrine response to visual threats, there is uncertainty about the role of subcortical visual pathways in this process. Primates in general appear to depend less on subcortical visual pathways than other mammals. Yet, imaging studies continue to indicate a role for the superior colliculus and pulvinar nucleus in fear activation, despite disconnects in how these brain structures communicate not only with each other but with the amygdala. Studies in fish and amphibians suggest that the neuroendocrine response to visual threats has remained relatively unchanged for hundreds of millions of years, yet there are still significant data gaps with respect to how visual information is relayed to telencephalic areas homologous to the CeA, particularly in fish. In fact ray finned fishes may have evolved an entirely different mechanism for relaying visual information to the telencephalon. In part because they lack a pathway homologous to the lateral geniculate-striate cortex pathway of mammals, amphibians continue to be an excellent model for studying how stress hormones in turn modulate fear activating visual pathways. Glucocorticoids, melanocortin peptides, and CRF all appear to play some role in modulating sensorimotor processing in the optic tectum. These observations, coupled with data showing control of the hypothalamus-pituitary-adrenal axis by the superior colliculus, suggest a fear/stress/anxiety neuroendocrine circuit that begins with first order synapses in subcortical visual pathways. Thus, comparative studies shed light not only on how fear triggering visual pathways came to be, but how hormones released as a result of this activation modulate these pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.