Trial reportProceedings of the National Academy of Sciences of the United States of America2015
The human hippocampus contributes to both the recollection and familiarity components of recognition memory.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- An Investigation of the Modulating Effects of Sensory Stimulation and Transcranial Magnetic Stimulation on Memory-Related Brain Activity.Brain sciences · 2025Article
- The Effects of External Cue Overlap and Internal Goals on Selective Memory Retrieval as Revealed by Electroencephalographic (EEG) Neural Pattern Reinstatement.The European journal of neuroscience · 2025Article
- Unexpected Twists: Electrophysiological Correlates of Encoding and Retrieval of Events Eliciting Prediction Error.Psychophysiology · 2025Article
- The role of theta and gamma oscillations in item memory, source memory, and memory confidence.Psychophysiology · 2024Article
- Comparing episodic memory outcomes from walking augmented reality and stationary virtual reality encoding experiences.Scientific reports · 2024Article
- No evidence that visual impulses enhance the readout of retrieved long-term memory contents from EEG activity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The role of theta and gamma oscillations in item memory, source memory, and memory confidence.bioRxiv : the preprint server for biology · 2023Article
- Transforming experiences: Neurobiology of memory updating/editing.Frontiers in systems neuroscience · 2023Review
- Studying memory processes at different levels with simultaneous depth and surface EEG recordings.Frontiers in human neuroscience · 2023Article
- A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice.Metabolites · 2022Article
- Magnetoencephalography can reveal deep brain network activities linked to memory processes.Human brain mapping · 2022Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks.Scientific reports · 2022Article
- Dopamine activity on the perceptual salience for recognition memory.Frontiers in behavioral neuroscience · 2022Review
- No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study.Frontiers in aging neuroscience · 2022Article
- Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality.Journal of neural engineering · 2020Review
- Differential Generation of Saccade, Fixation, and Image-Onset Event-Related Potentials in the Human Mesial Temporal Lobe.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Despite a substantial body of work comprising theoretical modeling, the effects of medial temporal lobe lesions, and electrophysiological signal analysis, the role of the hippocampus in recognition memory remains controversial. In particular, it is not known whether the hippocampus exclusively supports recollection or both recollection and familiarity--the two latent cognitive processes theorized to underlie recognition memory. We studied recognition memory in a large group of patients undergoing intracranial electroencephalographic (iEEG) monitoring for epilepsy. By measuring high-frequency activity (HFA)--a signal associated with precise spatiotemporal properties--we show that hippocampal activity during recognition predicted recognition memory performance and tracked both recollection and familiarity. Through the lens of dual-process models, these results indicate that the hippocampus supports both the recollection and familiarity processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.