ArticleProceedings of the National Academy of Sciences of the United States of America2015
Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- Melatonin promotes stomatal immunity by mediating phytohormone crosstalk inFrontiers in plant science · 2026Article
- CsCOI1 regulates plant growth and defense in citrus.Horticulture research · 2025Article
- The hidden language of plant-beneficial microbes: chemo-signaling dynamics in plant microenvironments.World journal of microbiology & biotechnology · 2025Review
- Comparative analyses of RNA-seq and phytohormone data of sweetpotatoes inoculated with Dickeya dadantii causing bacterial stem and root rot of sweetpotato.BMC plant biology · 2024Article
- Article
- JAZ is essential for ligand specificity of the COI1/JAZ co-receptor.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Systematic comparison of differential expression networks in MTB mono-, HIV mono- and MTB/HIV co-infections for drug repurposing.PLoS computational biology · 2022Article
- Exploring the interaction mechanism between antagonist and the jasmonate receptor complex by molecular dynamics simulation.Journal of computer-aided molecular design · 2022Article
- Salicylic Acid Is Required for Broad-Spectrum Disease Resistance in Rice.International journal of molecular sciences · 2022Article
- MYC2-ActivatedPlant physiology · 2020Article
- Molecular Rewiring of the Jasmonate Signaling Pathway to Control Auxin-Responsive Gene Expression.Cells · 2020Article
- Recent Advances in Plant Chemical Biology of Jasmonates.International journal of molecular sciences · 2020Review
- Genetic modification to improve disease resistance in crops.The New phytologist · 2020Review
- Bacillus subtilis CBR05 induces Vitamin B6 biosynthesis in tomato through the de novo pathway in contributing disease resistance against Xanthomonas campestris pv. vesicatoria.Scientific reports · 2019Article
- The Crosstalks Between Jasmonic Acid and Other Plant Hormone Signaling Highlight the Involvement of Jasmonic Acid as a Core Component in Plant Response to Biotic and Abiotic Stresses.Frontiers in plant science · 2019Review
- The Arabidopsis RNA Polymerase II Carboxyl Terminal Domain (CTD) Phosphatase-Like1 (CPL1) is a biotic stress susceptibility gene.Scientific reports · 2018Article
- A rationally designed JAZ subtype-selective agonist of jasmonate perception.Nature communications · 2018Article
- Ligand-receptor co-evolution shaped the jasmonate pathway in land plants.Nature chemical biology · 2018Article
- Trans-species synthetic gene design allows resistance pyramiding and broad-spectrum engineering of virus resistance in plants.Plant biotechnology journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
In the past decade, characterization of the host targets of pathogen virulence factors took a center stage in the study of pathogenesis and disease susceptibility in plants and humans. However, the impressive knowledge of host targets has not been broadly exploited to inhibit pathogen infection. Here, we show that host target modification could be a promising new approach to "protect" the disease-vulnerable components of plants. In particular, recent studies have identified the plant hormone jasmonate (JA) receptor as one of the common targets of virulence factors from highly evolved biotrophic/hemibiotrophic pathogens. Strains of the bacterial pathogen Pseudomonas syringae, for example, produce proteinaceous effectors, as well as a JA-mimicking toxin, coronatine (COR), to activate JA signaling as a mechanism to promote disease susceptibility. Guided by the crystal structure of the JA receptor and evolutionary clues, we succeeded in modifying the JA receptor to allow for sufficient endogenous JA signaling but greatly reduced sensitivity to COR. Transgenic Arabidopsis expressing this modified receptor not only are fertile and maintain a high level of insect defense, but also gain the ability to resist COR-producing pathogens Pseudomonas syringae pv. tomato and P. syringae pv. maculicola. Our results provide a proof-of-concept demonstration that host target modification can be a promising new approach to prevent the virulence action of highly evolved pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.