ArticleNucleic acids research2016
PANTHER version 10: expanded protein families and functions, and analysis tools.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 487 papers, 3 of them syntheses that pooled it.
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Who cites it
487 citing papers in PubMed, 3 syntheses or guidelines pooled it.
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- Plasticity of intestinal gene expression profile signatures reflected by nutritional interventions in piglets.BMC genomics · 2019Pooled it
- Ancestry and genetic associations with bronchopulmonary dysplasia in preterm infants.American journal of physiology. Lung cellular and molecular physiology · 2018Trial
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- Comparative genomics analyses reveal genomic variation and evolutionary adaptation in Dendrobium orchids.Nature communications · 2025Article
- Spatiotemporal localization of jasmonate in the regulation of fruit set in tomato.Journal of experimental botany · 2025Article
- Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation.bioRxiv : the preprint server for biology · 2025Article
- A pro-angiogenic and hypoxic zebrafish model as a novel platform for anti-angiogenic drug testing.Biology open · 2025Article
- A chromosomal-level genome assembly of Araneus marmoreus Schenkel, 1953 (Araneae: Araneidae).Scientific data · 2025Article
- In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism.BMC genomics · 2025Article
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- Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis.iScience · 2024Article
- GOAT: efficient and robust identification of gene set enrichment.Communications biology · 2024Article
- Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia.Molecular therapy. Nucleic acids · 2024Article
427 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
PANTHER (Protein Analysis THrough Evolutionary Relationships, http://pantherdb.org) is a widely used online resource for comprehensive protein evolutionary and functional classification, and includes tools for large-scale biological data analysis. Recent development has been focused in three main areas: genome coverage, functional information ('annotation') coverage and accuracy, and improved genomic data analysis tools. The latest version of PANTHER, 10.0, includes almost 5000 new protein families (for a total of over 12 000 families), each with a reference phylogenetic tree including protein-coding genes from 104 fully sequenced genomes spanning all kingdoms of life. Phylogenetic trees now include inference of horizontal transfer events in addition to speciation and gene duplication events. Functional annotations are regularly updated using the models generated by the Gene Ontology Phylogenetic Annotation Project. For the data analysis tools, PANTHER has expanded the number of different 'functional annotation sets' available for functional enrichment testing, allowing analyses to access all Gene Ontology annotations--updated monthly from the Gene Ontology database--in addition to the annotations that have been inferred through evolutionary relationships. The Prowler (data browser) has been updated to enable users to more efficiently browse the entire database, and to create custom gene lists using the multiple axes of classification in PANTHER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.