Evidence map›Paper›PMID 26578589›Full record

ArticleNucleic acids research2016

ORegAnno 3.0: a community-driven resource for curated regulatory annotation.

Robert Lesurf, Kelsy C Cotto, Grace Wang, Malachi Griffith, Katayoon Kasaian, Steven J M Jones, Stephen B Montgomery, Obi L Griffith, Open Regulatory Annotation Consortium

Abstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. UnlockingNAR genomics and bioinformatics · 2026
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert LesurfMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
Kelsy C CottoMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
Grace WangMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
Malachi GriffithMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Katayoon KasaianCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Stephen B MontgomeryDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA smontgom@stanford.edu.
Obi L GriffithMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA ogriffit@genome.wustl.edu.ORCID http://orcid.org/0000-0002-0843-4271
Open Regulatory Annotation Consortium

Funding

Methods for high-resolution analysis of genetic effects on gene expressionR01MH101814 · NIMH · UNIVERSITY OF GENEVA · PI BUSTAMANTE, CARLOS DANIEL, DERMITZAKIS, EMMANOUIL · 2013 to 2016
$2.3M
Predicting causal non-coding variants in a founder populationR01HG008150 · NHGRI · STANFORD UNIVERSITY · PI MONTGOMERY, STEPHEN · 2015 to 2017
$1.4M
Integrated Analysis & Interpretation of Whole Genome Exome & Transcriptome SequenR00HG007940 · NHGRI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2017 to 2019
$724k
DEFINING THE REGULATORY, NON-CODING, MUTATIONAL LANDSCAPE OF BREAST CANCERK22CA188163 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, OBI L. · 2014 to 2016
$515k
INTEGRATED ANALYSIS & INTERPRETATION OF WHOLE GENOME, EXOME & TRANSCRIPTOME SEQUENCE DATA IN CANCERK99HG007940 · NHGRI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2015 to 2016
$264k
NCI NIH HHS K22 CA188163NCI NIH HHS K22CA188163NHGRI NIH HHS K99 HG007940NHGRI NIH HHS K99HG007940NHGRI NIH HHS R00 HG007940NHGRI NIH HHS R01 HG008150NHGRI NIH HHS R01HG008150NIMH NIH HHS R01MH101814
6 · The paper itself

Abstract

The Open Regulatory Annotation database (ORegAnno) is a resource for curated regulatory annotation. It contains information about regulatory regions, transcription factor binding sites, RNA binding sites, regulatory variants, haplotypes, and other regulatory elements. ORegAnno differentiates itself from other regulatory resources by facilitating crowd-sourced interpretation and annotation of regulatory observations from the literature and highly curated resources. It contains a comprehensive annotation scheme that aims to describe both the elements and outcomes of regulatory events. Moreover, ORegAnno assembles these disparate data sources and annotations into a single, high quality catalogue of curated regulatory information. The current release is an update of the database previously featured in the NAR Database Issue, and now contains 1 948 307 records, across 18 species, with a combined coverage of 334 215 080 bp. Complete records, annotation, and other associated data are available for browsing and download at http://www.oreganno.org/.

Indexed as

Databases, Nucleic AcidMolecular Sequence AnnotationRegulatory Sequences, Nucleic AcidBinding SitesRNATranscription FactorsRNATranscription Factors

Identifiers

PMID26578589
PMCPMC4702855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.