Evidence map›Paper›PMID 26578578›Full record

ArticleNucleic acids research2016

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage.

Eric A Josephs, D Dewran Kocak, Christopher J Fitzgibbon, Joshua McMenemy, Charles A Gersbach, Piotr E Marszalek

Abstract readPublished Erratum
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a).Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Eric A JosephsDepartment of Mechanical Engineering and Materials Science, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA eaj20@duke.edu.
D Dewran KocakDepartment of Biomedical Engineering, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA.
Christopher J FitzgibbonDepartment of Mechanical Engineering and Materials Science, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA.
Joshua McMenemyDepartment of Biomedical Engineering, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA.
Charles A GersbachDepartment of Biomedical Engineering, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Piotr E MarszalekDepartment of Mechanical Engineering and Materials Science, Edmund T. Pratt, Jr. School of Engineering, Duke University, Durham, NC 27708, USA eaj20@duke.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID26578578
PMCPMC4797275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.