Evidence map›Paper›PMID 26578531›Full record

ArticleEuropean journal of nutrition2017

Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia.

Ping Liu, Min Zhang, Xing Xie, Jie Jin, C D'Arcy J Holman

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Green tea (Camellia sinensis) for the prevention of cancer.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Review
  4. The Effects of Green Tea Catechins in Hematological Malignancies.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Ping LiuSchool of Population Health, The University of Western Australia, M431, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia. ping.liu@research.uwa.edu.au.
Min ZhangSchool of Population Health, The University of Western Australia, M431, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia.
Xing XieWomen's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, People's Republic of China.
Jie JinDepartment of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, People's Republic of China.
C D'Arcy J HolmanSchool of Population Health, The University of Western Australia, M431, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia.
University of Western Australia · AUFirst Affiliated Hospital Zhejiang University · CNMacquarie University · AUWomen's Hospital, School of Medicine, Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGreen tea may have a beneficial role of inhibiting leukemia. Glutathione S-transferases (GSTs) are known to detoxify certain carcinogens. We investigated the roles of green tea consumption and polymorphisms of GSTM1, GSTT1 and GSTP1 on the risk of adult leukemia, and to determine whether the associations varied within GSTs genotypes.

methodsA multicenter case-control study was conducted in China, 2008-2013. It comprised 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium and study site. Data were collected by face-to-face interview using a validated questionnaire. Genetic polymorphisms were assayed by PCR.

resultsAn inverse association between green tea consumption and adult leukemia risk was observed. Compared with non-tea drinkers, the adjusted odds ratios (95 % confidence intervals) were 0.50 (0.27-0.93), 0.31 (0.17-0.55) and 0.53 (0.29-0.99) for those who, respectively, consumed green tea >20 years, ≥2 cups daily and dried tea leaves >1000 g annually. In assessing the associations by GSTs genotypes, risk reduction associated with green tea consumption was stronger in individuals with the GSTT1-null genotype (OR 0.24; 95 % CI 0.11-0.53) than GSTT1-normal carriers (OR 0.67; 95 % CI 0.42-1.05; P interaction = 0.02). GSTM1 and GSTP1 did not significantly modify the inverse association of leukemia with green tea.

conclusionsThe results suggest that regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype and highlights further study.

Indexed as

TeaAdultAgedCase-Control StudiesChinaDietFemaleGenetic Predisposition to DiseaseGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansLeukemiaMaleMiddle AgedPolymerase Chain ReactionGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseTeaAdult leukemiaGene–diet interactionGenetic polymorphismGreen teaGST

Identifiers

PMID26578531
OpenAlexW2180748303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.