Evidence map›Paper›PMID 26578523›Full record

ReviewHandbook of experimental pharmacology2016

Neural Control of Energy Expenditure.

Heike Münzberg, Emily Qualls-Creekmore, Hans-Rudolf Berthoud, Christopher D Morrison, Sangho Yu

Abstract readReview
In one paragraph

Review in Handbook of experimental pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
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  10. Review
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  14. Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Leptin and brain-adipose crosstalks.Nature reviews. Neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Heike MünzbergPennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA. Heike.Munzberg@pbrc.edu.
Emily Qualls-CreekmorePennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.
Hans-Rudolf BerthoudPennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.
Christopher D MorrisonPennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.
Sangho YuPennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.
Louisiana State University System · USPennington Biomedical Research Center · US

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Neural mechanisms controlling food intake and body weight after bariatric surgeryR01DK047348 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BERTHOUD, HANS-RUDOLF · 1994 to 2018
$5.0M
Leptin and Central Control of ThermoregulationR01DK092587 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2012 to 2024
$3.5M
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK047348NIDDK NIH HHS R01 DK092587NIDDK NIH HHS T32 DK064584
6 · The paper itself

Abstract

The continuous rise in obesity is a major concern for future healthcare management. Many strategies to control body weight focus on a permanent modification of food intake with limited success in the long term. Metabolism or energy expenditure is the other side of the coin for the regulation of body weight, and strategies to enhance energy expenditure are a current focus for obesity treatment, especially since the (re)-discovery of the energy depleting brown adipose tissue in adult humans. Conversely, several human illnesses like neurodegenerative diseases, cancer, or autoimmune deficiency syndrome suffer from increased energy expenditure and severe weight loss. Thus, strategies to modulate energy expenditure to target weight gain or loss would improve life expectancies and quality of life in many human patients. The aim of this book chapter is to give an overview of our current understanding and recent progress in energy expenditure control with specific emphasis on central control mechanisms.

Indexed as

Energy MetabolismAdaptation, PhysiologicalAnimalsBrainBrain StemHumansHypothalamusThermogenesisBody weightDorsomedial hypothalamusFGF21HormonesHypothalamusLeptinNeuronal circuits

Identifiers

PMID26578523
PMCPMC4818114
OpenAlexW2249523439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.