ArticleAge (Dordrecht, Netherlands)2015
Effects of white matter lesions on trunk stability during dual-task walking among older adults with mild cognitive impairment.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Neural correlates of dual-task walking in people with central neurological disorders: a systematic review.Journal of neurology · 2022Pooled it
- Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2022Pooled it
- Sensorized Motor and Cognitive Dual Task Framework for Dementia Diagnosis: Preliminary Insights From a Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Knee sleeves improve gait symmetry during fast walking in older adults.Frontiers in bioengineering and biotechnology · 2024Article
- Relationships between Gait Regularity and Cognitive Function, including Cognitive Domains and Mild Cognitive Impairment, in Community-Dwelling Older People.Healthcare (Basel, Switzerland) · 2021Article
- Functional capacity and dual-task cost in the institutionalized older adults, both affected and unaffected by mild cognitive impairment.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2021Article
- Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection.Scientific reports · 2021Article
- Smoothness of Gait in Healthy and Cognitively Impaired Individuals: A Study on Italian Elderly Using Wearable Inertial Sensor.Sensors (Basel, Switzerland) · 2020Article
- Postural instability in cognitively impaired elderly during forward and backward body leans.Journal of physical therapy science · 2019Article
- Prevalence of white matter hyperintensities increases with age.Neural regeneration research · 2018Article
- Association between Various Brain Pathologies and Gait Disturbance.Dementia and geriatric cognitive disorders · 2017Review
- Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.Age (Dordrecht, Netherlands) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linkage between gait and cognition has been shown in cases of white matter lesion (WML) that affect gait in older adults. Dual-task walking is believed to be cognitively demanding and to alter trunk movement, and gait impairment in people with mild cognitive impairment (MCI) is highlighted under this condition. However, the association between dual-task walking and structural changes in the brain, particularly with WML, in people with MCI is still unclear. The aim of this study was to examine the association between trunk stability during dual-task walking and WML in 560 older adults with MCI. We measured magnetic resonance imaging (MRI) and gait variables. Gait variables included harmonic ratio in vertical, mediolateral, and anteroposterior directions, analyzed using a tri-axial accelerometer attached to the lower trunk. Walking conditions were normal walking and dual-task walking (counting backwards while walking) conditions. Demographical data and brain atrophy were measured as covariates. Subjects were classified into non-severe WML (n = 451, mean age = 73.2 years) and severe WML (n = 109, mean age = 75.9 years) groups. Linear mixed-effects model analysis controlled for covariates showed dual-task-related changes in all harmonic ratios associated with WML (p < 0.05). Even after adjustment for executive function, harmonic ratio in the mediolateral direction was significantly associated with WML (p < 0.05). Our findings revealed that WMLs were associated with trunk stability in dual-task walking. Further studies are required to investigate the neural basis for deficits in gait ability among MCI subjects.
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