ArticleSurgical endoscopy2016
Incidence, risk factors and consequences of bile leakage following laparoscopic major hepatectomy.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Risk factors of postoperative bile leakage after liver resection: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Safety and effectiveness of indocyanine green fluorescence imaging-guided laparoscopic hepatectomy for hepatic tumor: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Systematic review and meta-analysis of the efficacy of prophylactic abdominal drainage in major liver resections.Scientific reports · 2021Pooled it
- Meta-Analysis of Risk Factors for Bile Leakage After Hepatectomy Without Biliary Reconstruction.Frontiers in surgery · 2021Pooled it
- Advanced robotic liver surgery.Surgical endoscopy · 2026Review
- Application of left lateral hepatolithiasis classification in minimally invasive hepatectomy.Updates in surgery · 2026Article
- Article
- Risk factors for bile leakage after laparoscopic common bile duct exploration in older patients with choledocholithiasis.World journal of gastrointestinal surgery · 2025Article
- Impact of post-hepatectomy biliary leaks on long-term survival in different liver tumors: A single institute experience.Annals of hepato-biliary-pancreatic surgery · 2024Article
- Development of a novel difficulty scoring system for laparoscopic liver resection procedure in patients with intrahepatic duct stones.World journal of gastrointestinal surgery · 2024Article
- Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.Langenbeck's archives of surgery · 2024Article
- C-reactive Protein-to-Albumin Ratio: A Useful Predictor for Biliary Fistula After Hepatectomy.Cureus · 2024Article
- Novel Personalized Score Predicts Risk for Postoperative Biliary Leak in Liver Surgery-a Retrospective Database Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Validation of the IWATE criteria as a laparoscopic liver resection difficulty score in a single North American cohort.Surgical endoscopy · 2022Article
- Study: International Multicentric Minimally Invasive Liver Resection for Colorectal Liver Metastases (SIMMILR-CRLM).Cancers · 2022Article
- Risk factors and impact on bile leakage in patients with choledochal cysts: a retrospective case-control analysis.Updates in surgery · 2021Article
- Predictive ability of preoperative CT scan for the intraoperative difficulty and postoperative outcomes of laparoscopic liver resection.Surgical endoscopy · 2021Article
- A Japanese multi-institutional randomized controlled trial (ND-Trial).Hepatobiliary surgery and nutrition · 2021Article
- Leakage and Stenosis of the Hepaticojejunostomy Following Surgery for Perihilar Cholangiocarcinoma.Journal of clinical medicine · 2020Article
- Bile Leak Reduction with Laparoscopic Versus Open Liver Resection: A Multi-institutional Propensity Score-Adjusted Multivariable Regression Analysis.World journal of surgery · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBile leakage (BL) remains a common cause of major morbidity after open major liver resection but has only been poorly described in patients undergoing laparoscopic major hepatectomy (LMH). The present study aimed to determine the incidence, risk factors and consequences of BL following LMH.
methodsAll 223 patients undergoing LMH between 2000 and 2013 at two tertiary referral centres were retrospectively analysed. BL was defined according to the International Study Group of Liver Surgery, and its incidence and consequences were assessed. Risk factors for BL were determined on multivariate analysis.
resultsBL occurred in 30 (13.5 %) patients, and its incidence remained stable over time (p = 0.200). BL was diagnosed following the presence of bile into the abdominal drain in 14 (46.7 %) patients and after drainage of symptomatic abdominal collections in 16 (53.3 %) patients without intra-operative drain placement. Grade A, B and C BL occurred in 3 (10.0 %), 23 (76.6 %) and 4 (13.4 %) cases, respectively. Interventional procedures for BL included endoscopic retrograde cholangiography, percutaneous and surgical drainage in 10 (33.3 %), 23 (76.7 %) and 4 (13.3 %) patients, respectively. BL was associated with significantly increased rates of symptomatic pleural effusion (30.0 vs. 11.4 %, p = 0.006), multiorgan failure (13.3 vs. 3.6 %, p = 0.022), postoperative death (10.0 vs. 1.6 %, p = 0.008) and prolonged hospital stay (18 vs. 8 days, p < 0.001). On multivariable analysis, BMI > 28 kg/m(2) (OR 2.439, 95 % CI 1.878-2.771, p = 0.036), history of hepatectomy (OR 1.675, 95 % CI 1.256-2.035, p = 0.044) and biliary reconstruction (OR 1.975, 95 % CI 1.452-2.371, p = 0.039) were significantly associated with increased risk of BL. CONCLUSIONS AND RELEVANCE: After LMH, BL occurred in 13.5 % of the patients and was associated with significant morbidity. Patients with one or several risk factors for BL should benefit intra-operative drain placement.
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