ReviewMolecular ecology2016
The rate of adaptive evolution in animal mitochondria.
Review in Molecular ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed.
- Positive and relaxed selection on mitochondrial DNA in parasitic versus predatory mites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Genetic Diversity Impacts Climate-Induced Species Range Shifts.Ecology letters · 2026Review
- Patterns and determinants of mitogenomic evolution in Bilateria.Nature communications · 2026Article
- A full-length mtDNA dataset for studying genetic variations across generations and complex family structures.Scientific data · 2026Article
- Synonymous but not silent: functional codon bias reveals decoupled mitonuclear evolution in parasitic worms.Bioinformatics advances · 2026Article
- Haplodiploidy accelerates mitogenome evolution in insects.Proceedings. Biological sciences · 2025Article
- Comparative mitogenomics reveals evolutionary drivers of Strongyloidea nematodes dwelling in gastrointestinal tract.BMC genomics · 2025Article
- Comparative Mitogenomic Analysis of ThreeInsects · 2025Article
- Mitochondrial transplantation: adaptive bio-enhancement.Cell death & disease · 2025Article
- Comparative analysis of the mitochondrial genome of Carpodacus erythrinus (Passeriformes: Fringillidae) across different altitudes.Molecular biology reports · 2025Article
- Mitochondrial Genome Variations and Possible Adaptive Implications in Some Tephritid Flies (Diptera, Tephritidae).International journal of molecular sciences · 2025Article
- Equus mitochondrial pangenome reveals independent domestication imprints in donkeys and horses.Scientific reports · 2025Article
- Article
- DNA barcoding of passerine birds in Iran.ZooKeys · 2025Article
- Evolutionary history and divergence times of Tettigoniidae (Orthoptera) inferred from mitochondrial phylogenomics.Frontiers in genetics · 2025Article
- Complete Mitochondrial Genomes ofGenes · 2024Article
- Nuclear compensatory evolution driven by mito-nuclear incompatibilities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential Mitochondrial Genome Expression of Three Sympatric Lizards in Response to Low-Temperature Stress.Animals : an open access journal from MDPI · 2024Article
- An efficient and robust ABC approach to infer the rate and strength of adaptation.G3 (Bethesda, Md.) · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated whether there is adaptive evolution in mitochondrial DNA, using an extensive data set containing over 500 animal species from a wide range of taxonomic groups. We apply a variety of McDonald-Kreitman style methods to the data. We find that the evolution of mitochondrial DNA is dominated by slightly deleterious mutations, a finding which is supported by a number of previous studies. However, when we control for the presence of deleterious mutations using a new method, we find that mitochondria undergo a significant amount of adaptive evolution, with an estimated 26% (95% confidence intervals: 5.7-45%) of nonsynonymous substitutions fixed by adaptive evolution. We further find some weak evidence that the rate of adaptive evolution is correlated to synonymous diversity. We interpret this as evidence that at least some adaptive evolution is limited by the supply of mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.