Trial reportClinical oral investigations2016
Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial.
Trial report in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06398327 (Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents), which is not on this map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents: A Comparative Study Featuring A Novel Biomarker For Pulpal Diagnosis
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Clinical and radiographic outcomes of pulpotomy materials in permanent teeth: a systematic review of calcium hydroxide, MTA, biodentine, and iRoot BP plus.BMC oral health · 2025Pooled it
- Systematic review and meta analysis of first and second generation bioceramic materials in primary dentition pulpotomies.Scientific reports · 2025Pooled it
- MTA and biodentine for primary teeth pulpotomy: a systematic review and meta-analysis of clinical trials.Clinical oral investigations · 2019Pooled it
- Pulp treatment for extensive decay in primary teeth.The Cochrane database of systematic reviews · 2018Pooled it
- Pulpotomy of deciduous molars with deep caries using three different hydraulic calcium silicate cements: a short-term pilot randomized controlled split-mouth study.Clinical oral investigations · 2026Trial
- Eggshell powder as a biomimetic alternative to biodentine in primary teeth pulpotomy: a comparative clinical and radiographic study.Scientific reports · 2026Trial
- Histopathological and immunohistochemical characterization of pulp tissue reaction to ACTIVA BioACTIVE base/liner in primary teeth pulpotomy: a randomized clinical trial.BMC oral health · 2025Trial
- Trial
- Clinical efficacy of Er:YAG laser application in pulpotomy of primary molars: a 2-year follow-up study.Lasers in medical science · 2022Trial
- Long-term evaluation of primary teeth molar pulpotomies with Biodentine and MTA: a CONSORT randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial.Clinical oral investigations · 2021Trial
- The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth.Clinical oral investigations · 2019Trial
- BiodentineBMC oral health · 2019Trial
- Success Rates of Pulpotomies in Primary Molars Using Calcium Silicate-Based Materials: A Randomized Control Trial.BioMed research international · 2017Trial
- Comparison of Eggshell-derived Calcium Hydroxyapatite and Biodentine as Indirect Pulp-capping Agents in Primary Molars:International journal of clinical pediatric dentistry · 2026Article
- Comparison of calcium silicate-based materials in pulpotomies of primary molars: a randomized clinical trial.European oral research · 2025Article
- Success of pulpotomy with MTA in primary teeth: A systematic review and meta-analysis.Bioinformation · 2025Article
- Comparative evaluation of step-wise caries excavation and indirect pulp capping for vitality preservation in young permanent teeth: AnBioinformation · 2025Article
- Pulpotomy in primary teeth: Biodentine™ versus calcium hydroxide. A systematic review and meta-analysis.The Saudi dental journal · 2024Review
- Clinical and radiographic success of pulpotomy and pulpectomy in primary and permanent teeth: a Systematic Review and Meta-Analysis.Journal of clinical and experimental dentistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAn ideal pulpotomy agent for primary molars has been sought for many years. Recently, new materials that allow regeneration of residual pulp tissue have been developed. In this study, we compared the preliminary clinical results obtained using Biodentine and mineral trioxide aggregate (MTA) as pulp-dressing agents in pulpotomies of primary molars.
methodsA randomized clinical study was performed in children aged 4-9 years with at least one primary tooth with decay or caries requiring pulp treatment. A total of 90 primary molars requiring pulpotomy were randomly allocated to the MTA or Biodentine group, and 84 pulpotomies were performed. Clinical and radiographic evaluations were undertaken 6 and 12 months after treatment. All teeth were restored with a reinforced zinc oxide-eugenol base and stainless steel crowns. Statistical analysis using Fisher's exact test was performed to determine the significant differences between the groups.
resultsA total of four clinical failures were observed; all involved gingival inflammation. The clinical success rate in the MTA Group after 12 months was 92 % (36/39), whereas the Biodentine Group obtained 97 % (38/39) (p = 0.346). All radiographic failures were observed at the 12-month follow-up evaluation. One molar from MTA Group showed internal resorption obtaining a radiographic success rate of 97 % (38/39). Two molars from the Biodentine Group showed radiographic failure (1 internal resorption and 1 periradicular radiolucency) obtaining a radiographic success rate of 95 % (37/39).
conclusionsBiodentine showed similar clinical results as MTA with comparable success rates when used for pulpotomies of primary molars. However, longer follow-up studies are required to confirm our findings. CLINICAL RELEVANCE: This article demonstrates the effectiveness of Biodentine as a primary teeth pulpotomy material, performing similar results as MTA at 12-months evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.