Evidence map›Paper›PMID 26578066›Full record

ArticleFEBS letters2015

Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.

Kimberly M Maize, Elbek K Kurbanov, Rodney L Johnson, Elizabeth Ambrose Amin, Barry C Finzel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly M MaizeDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, 8-101 Weaver-Densford Hall, Minneapolis, MN 55455, United States.
Elbek K KurbanovDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, 8-101 Weaver-Densford Hall, Minneapolis, MN 55455, United States.
Rodney L JohnsonDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, 8-101 Weaver-Densford Hall, Minneapolis, MN 55455, United States.
Elizabeth Ambrose AminDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, 8-101 Weaver-Densford Hall, Minneapolis, MN 55455, United States.
Barry C FinzelDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard St SE, 8-101 Weaver-Densford Hall, Minneapolis, MN 55455, United States. Electronic address: finze007@umn.edu.
University of Minnesota · US

Funding

Anthrax Toxin Lethal Factor Inhibition StudyR01AI083234 · NIAID · UNIVERSITY OF MINNESOTA · PI AMBROSE, ELIZABETH ANN · 2009 to 2012
$1.9M
NIAID NIH HHS R01 AI083234
6 · The paper itself

Abstract

The Bacillus anthracis lethal factor (LF) is one component of a tripartite exotoxin partly responsible for persistent anthrax cytotoxicity after initial bacterial infection. Inhibitors of the zinc metalloproteinase have been investigated as potential therapeutic agents, but LF is a challenging target because inhibitors lack sufficient selectivity or possess poor pharmaceutical properties. These structural studies reveal an alternate conformation of the enzyme, induced upon binding of specific inhibitors, that opens a previously unobserved deep pocket termed S1'(∗) which might afford new opportunities to design selective inhibitors that target this subsite.

Indexed as

Antigens, BacterialBacterial ToxinsBinding SitesLigandsMatrix Metalloproteinase InhibitorsModels, MolecularProtein ConformationStructure-Activity RelationshipTyrosineanthrax toxinAntigens, BacterialBacterial ToxinsLigandsMatrix Metalloproteinase InhibitorsTyrosineAnthraxConformational changeLethal factorLigand-inducedStructure-based drug designZinc hydrolase

Identifiers

PMID26578066
PMCPMC4688111
OpenAlexW2178652713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.