ArticleEuropean journal of nuclear medicine and molecular imaging2016
Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [(11)C] DASB positron emission tomography study.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta-Analyses.Diabetes, obesity & metabolism · 2026Pooled it
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Central noradrenaline transporter availability in highly obese, non-depressed individuals.European journal of nuclear medicine and molecular imaging · 2017Trial
- Article
- Central Serotonin/Noradrenaline Transporter Availability and Treatment Success in Patients with Obesity.Brain sciences · 2022Article
- HPA Axis Responsiveness Associates with Central Serotonin Transporter Availability in Human Obesity and Non-Obesity Controls.Brain sciences · 2022Article
- Serotonin transporter is negatively associated with body mass index after glucose loading in humans.Brain imaging and behavior · 2022Article
- False positive rates in positron emission tomography (PET) voxelwise analyses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Serotonin, food intake, and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
- Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity.Scientific reports · 2020Article
- Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis.Frontiers in neuroscience · 2020Article
- Decreased Conflict Control in Overweight Chinese Females: Behavioral and Event-Related Potentials Evidence.Nutrients · 2019Article
- Noradrenaline transporter availability on [European journal of nuclear medicine and molecular imaging · 2018Article
- The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters.Scientific reports · 2018Article
- Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity.Translational psychiatry · 2017Article
- Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans.Neuroendocrinology · 2017Article
- Sex differences in serotonin-hypothalamic connections underpin a diminished sense of emotional well-being with increasing body weight.International journal of obesity (2005) · 2016Article
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Authors and funding
21 authors.
Funding
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Abstract
purposeThe role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of human obesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies of central 5-HTT availability have been inconsistent, which is thought to be brought about mainly by the low number of individuals with a high body mass index (BMI) previously used. The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls.
methodsWe performed PET using the 5-HTT selective radiotracer [(11)C] DASB on 30 highly obese (BMI range between 35 and 55 kg/m(2)) and 15 age- and sex-matched non-obese volunteers (BMI range between 19 and 27 kg/m(2)) in a cross-sectional study design. The 5-HTT binding potential (BPND) was used as the outcome parameter.
resultsOn a group level, there was no significant difference in 5-HTT BPND in various cortical and subcortical regions in individuals with the highest BMI compared with non-obese controls, while statistical models showed minor effects of age, sex, and the degree of depression on 5-HTT BPND.
conclusionThe overall finding of a lack of significantly altered 5-HTT availability together with its high variance in obese individuals justifies the investigation of individual behavioral responses to external and internal cues which may further define distinct phenotypes and subgroups in human obesity.
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