Evidence map›Paper›PMID 26577758›Full record

ReviewNeuroscience2016

Cellular and circuit models of increased resting-state network gamma activity in schizophrenia.

R S White, S J Siegel

Abstract readReview
In one paragraph

Review in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

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  20. Biomarkers in schizophrenia - past, present and future.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R S WhiteDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States.
S J SiegelDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: siegels@upenn.edu.
University of Pennsylvania · US

Funding

NMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BILKER, WARREN B. · 2012 to 2016
$10.6M
Src mediates molecular alterations leading to NMDAR hypofunction in schizophreniaR01MH075916 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BORGMANN-WINTER, KARIN, HAHN, CHANG-GYU · 2006 to 2019
$3.3M
An Implantable Semiannual Antipsychotic Delivery SystemR01MH074672 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, STEVEN J · 2007 to 2014
$2.3M
Long-term neurobehavioral effects of ketamine exposure in adolescent miceR01DA023210 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, STEVEN J · 2008 to 2012
$1.9M
NIDA NIH HHS R01 DA023210NIMH NIH HHS P50 MH096891NIMH NIH HHS R01 MH074672NIMH NIH HHS R01 MH075916
6 · The paper itself

Abstract

Schizophrenia (SCZ) is a disorder characterized by positive symptoms (hallucinations, delusions), negative symptoms (blunted affect, alogia, reduced sociability, and anhedonia), as well as persistent cognitive deficits (memory, concentration, and learning). While the biology underlying subjective experiences is difficult to study, abnormalities in electroencephalographic (EEG) measures offer a means to dissect potential circuit and cellular changes in brain function. EEG is indispensable for studying cerebral information processing due to the introduction of techniques for the decomposition of event-related activity into its frequency components. Specifically, brain activity in the gamma frequency range (30-80Hz) is thought to underlie cognitive function and may be used as an endophenotype to aid in diagnosis and treatment of SCZ. In this review we address evidence indicating that there is increased resting-state gamma power in SCZ. We address how modeling this aspect of the illness in animals may help treatment development as well as providing insights into the etiology of SCZ.

Indexed as

Disease Models, AnimalGamma RhythmAnimalsBrainHumansMaleSchizophreniaEEGgammaschizophrenia

Identifiers

PMID26577758
PMCPMC4803631
OpenAlexW2147309902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.