Evidence map›Paper›PMID 26577516›Full record

ArticleHarm reduction journal2015

Why the FUSS (Fentanyl Urine Screen Study)? A cross-sectional survey to characterize an emerging threat to people who use drugs in British Columbia, Canada.

Ashraf Amlani, Geoff McKee, Noren Khamis, Geetha Raghukumar, Erica Tsang, Jane A Buxton

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Harm reduction journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03373825 (Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs), which is not on this map. Cited by 72 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03373825 nacompletednot on this mapstarted 2017, after this paper: background citation

Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs

TypeinterventionalSponsorBrown UniversityRan2017 to 2017Enrolled93ConditionsAccidental Overdose of OpiateArmsTake home rapid drug test
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
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  4. Effects of opioids and stimulants on the respiratory system.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ashraf AmlaniBritish Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4, Canada. ashraf.amlani@bccdc.ca.
Geoff McKeeSchool of Public and Population Health, University of British Columbia, Vancouver, Canada. gwmckee@gmail.com.
Noren KhamisFaculty of Medicine, University of British Columbia, Vancouver, Canada. noren.khamis@gmail.com.
Geetha RaghukumarFaculty of Medicine, University of British Columbia, Vancouver, Canada. geetharaghukumar@gmail.com.
Erica TsangFaculty of Medicine, University of British Columbia, Vancouver, Canada. ertsang@alumni.ubc.ca.
Jane A BuxtonBritish Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4, Canada. jane.buxton@bccdc.ca.
University of British Columbia · CABC Centre for Disease Control · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFentanyl-detected illicit drug overdose deaths in British Columbia (BC) recently increased dramatically from 13 deaths in 2012 to 90 deaths in 2014, signaling an emerging public health concern. Illicit fentanyl is sold as pills or powders, often mixed with other substances like heroin or oxycodone; reports from coroners suggested that fentanyl was frequently taken unknowingly by people who use drugs. This study aimed to assess the prevalence and characteristics of fentanyl use among clients accessing harm reduction (HR) services in BC.

methodsParticipants attending HR services at 17 sites across BC were invited to complete an anonymous questionnaire describing drugs they have used within the last 3 days and provide a urine sample to test for fentanyl. Data from eligible participants were analyzed using descriptive, bivariate, and multivariate statistical methods.

resultsSurveys from 17 HR sites were received, resulting in analysis of responses from 242 eligible participants. Most participants used multiple substances (median = 3), with crystal meth (59%) and heroin (52%) use most frequently reported. Seventy participants (29%) tested positive for fentanyl, 73% of whom did not report using fentanyl. Controlling for age, gender, and health authority, reported use of fentanyl (odds ratio (OR) = 6.13, 95% confidence interval (CI) = [2.52, 15.78], p < 0.001) and crystal methamphetamine (OR = 3.82, 95% CI = [1.79, 8.63], p < 0.001) use were significantly associated with fentanyl detection.

conclusionsThe proportion of those testing positive who did not report knowingly using fentanyl represents a considerable public health concern. The risk of overdose among this vulnerable population highlights the need for targeted HR strategies, such as increased accessibility to naloxone, overdose education, and urine screens.

Indexed as

AdultBritish ColumbiaCross-Sectional StudiesFemaleFentanylHumansMaleMiddle AgedNarcoticsPrevalenceSubstance Abuse DetectionSubstance-Related DisordersSurveys and QuestionnairesYoung AdultFentanylNarcotics

Identifiers

PMID26577516
PMCPMC4650899
OpenAlexW2175899874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.