ArticleScientific reports2015
Molecular basis of canalization in an ascidian species complex adapted to different thermal conditions.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A simple inland culture system provides insights into ascidian post-embryonic developmental physiology.Open biology · 2025Article
- Heat tolerance, oxidative stress response tuning and robust gene activation in early-stageProceedings. Biological sciences · 2024Article
- Heterogeneity in maternal mRNAs within clutches of eggs in response to thermal stress during the embryonic stage.BMC ecology and evolution · 2024Article
- Uncovering developmental time and tempo using deep learning.Nature methods · 2023Article
- Co-expression network analysis of environmental canalization in the ascidian Ciona.BMC ecology and evolution · 2022Article
- Chromosomal Inversion Polymorphisms in Two Sympatric Ascidian Lineages.Genome biology and evolution · 2021Article
- Asymmetric Fitness of Second-Generation Interspecific Hybrids BetweenG3 (Bethesda, Md.) · 2020Article
- ANISEED 2019: 4D exploration of genetic data for an extended range of tunicates.Nucleic acids research · 2020Article
- Chaperones, Canalization, and Evolution of Animal Forms.International journal of molecular sciences · 2018Review
- Maternal loading of a small heat shock protein increases embryo thermal tolerance inThe Journal of experimental biology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary change. Study of laboratory model species has uncovered several possible canalization mechanisms, however, we still do not understand how the level of buffering is controlled in natural populations. We exploit wild populations of the marine chordate Ciona intestinalis to show that levels of buffering are maternally inherited. Comparative transcriptomics show expression levels of genes encoding canonical chaperones such as Hsp70 and Hsp90 do not correlate with buffering. However the expression of genes encoding endoplasmic reticulum (ER) chaperones does correlate. We also show that ER chaperone genes are widely conserved amongst animals. Contrary to previous beliefs that expression level of Heat Shock Proteins (HSPs) can be used as a measurement of buffering levels, we propose that ER associated chaperones comprise a cellular basis for canalization. ER chaperones have been neglected by the fields of development, evolution and ecology, but their study will enhance understanding of both our evolutionary past and the impact of global environmental change.
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