ArticleJournal of neuroengineering and rehabilitation2015
Functional electrical stimulation through direct 4-channel nerve stimulation to improve gait in multiple sclerosis: a feasibility study.
Article in Journal of neuroengineering and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04758494 (A Study to Assess Quality of Life in Stroke and Multiple Sclerosis Patients of the Same Age Range), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Assess Quality of Life in Stroke and Multiple Sclerosis Patients of the Same Age Range
Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- The long-term effects of an implantable drop foot stimulator on gait in hemiparetic patients.PloS one · 2019Trial
- [Foot drop treatment by implantation of a neuroprosthesis (ActiGait®)].Operative Orthopadie und Traumatologie · 2017Trial
- Article
- Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Implanted Peroneal Nerve Stimulator Treatment for Drop Foot Caused by Central Nervous System Lesion: A Twelve-Month Follow-up of 21 Patients.Journal of rehabilitation medicine · 2022Article
- Advances in neuroprosthetic management of foot drop: a review.Journal of neuroengineering and rehabilitation · 2020Review
- Long-term outcomes of semi-implantable functional electrical stimulation for central drop foot.Journal of neuroengineering and rehabilitation · 2019Article
- Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.Journal of neuroscience research · 2018Review
- Recovery of facial expressions using functional electrical stimulation after full-face transplantation.Journal of neuroengineering and rehabilitation · 2018Article
- Evaluating the Effect of Functional Electrical Stimulation Used for Foot Drop on Aspects of Health-Related Quality of Life in People with Multiple Sclerosis: A Systematic Review.International journal of MS careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGait dysfunction due to lower limb central paralysis, frequently involving drop foot, is a common cause of disability in multiple sclerosis and has been treated with transcutaneous functional electrical stimulation (FES). We provide here the first report of 4-channel semi-implantable FES of the peroneal nerve which has been successfully used for rehabilitation in patients following stroke.
methodsFES was implemented via a 4-channel semi-implantable closed-loop system (ActiGait(®), ©Ottobock), generating dorsiflexion in drop foot. Walking distance, gait symmetry (temporospatial gait analyses, Vicon Motion Systems(®)), gait velocity (10 m walking test) and quality of life (SF-36 questionnaire) were measured to evaluate the therapeutic benefit of this system in two patients with progressive MS.
resultsWalking distance increased from 517 to 1884 m in Patient 1 and from 52 to 506 m in Patient 2. Gait velocity did not change significantly in Patient 1 and increased from 0.6 to 0.8 m/s in Patient 2. Maximum deviations of center of mass from the midline to each side changed significantly after 3 months of stimulation compared to baseline, decreasing from 15 to 12 mm in Patient 1 and from 47 to 37 mm in Patient 2. Both patients experienced reduced pain and fatigue and benefits to quality of life. Adverse events did not occur during the observation period.
conclusionWe conclude that implantable 4-channel FES systems are not only feasible but present a promising new alternative for treating central drop foot in MS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.