ReviewInternational journal of clinical oncology2016
Tumor hypoxia: a new PET imaging biomarker in clinical oncology.
Review in International journal of clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- A Review of Hypoxia Imaging Using 18F-Fluoromisonidazole Positron Emission Tomography.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Monofluoromethylation ofInternational journal of molecular sciences · 2023Review
- Four-dimensional quantitative analysis using FDG-PET in clinical oncology.Japanese journal of radiology · 2023Review
- Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.Biosensors · 2022Review
- My 42-year Experience in Radiation Oncology.Juntendo Iji zasshi = Juntendo medical journal · 2022Article
- Targeting Hypoxia Using Evofosfamide and Companion Hypoxia Imaging of FMISO-PET in Advanced Biliary Tract Cancer.Cancer research and treatment · 2021Article
- Increased [EJNMMI research · 2021Article
- Influence of the scan time point when assessing hypoxia inEuropean journal of nuclear medicine and molecular imaging · 2020Article
- The Roles of Hypoxia Imaging UsingJournal of clinical medicine · 2019Review
- Biodistribution and radiation dosimetry of the novel hypoxia PET probe [EJNMMI research · 2019Article
- A Novel PET Probe "[Molecular imaging and biology · 2019Article
- Noninvasive evaluation ofScientific reports · 2018Article
- FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state.Annals of nuclear medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor hypoxia is associated with tumor progression and resistance to various treatments. Noninvasive imaging using positron emission tomography (PET) and F-18-labeled fluoromisonidazole (FMISO) was recently introduced in order to define and quantify tumor hypoxia. The FMISO uptake was closely correlated with pimonidazole immunohistochemistry and hypoxia-inducible factor 1 expression in basic studies. Tumor hypoxia in head and neck cancers and other tumors in a clinical setting may also indicate resistance to radiation and/or chemotherapy. Hypoxic imaging may thus play a new and important role for suitable radiation planning, including dose escalation and dose reduction based on the image findings. Such radiation-dose painting based on the findings of hypoxia may require high-performance PET imaging to provide high target-to-background ratio images and an optimal quantitative parameter to define the hypoxic region. A multicenter prospective study using data from a large number of patients is also warranted to test the clinical value of hypoxic imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.