ArticleThe British journal of radiology2016
MRI may be used as a prognostic indicator in patients with extra-abdominal desmoid tumours.
Article in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Can MRI predict tumor behavior in desmoid-type fibromatosis during active surveillance?European radiology · 2026Article
- MRI assessment of tumor behavior in desmoid-type fibromatosis during active surveillance.European radiology · 2026Article
- MRI features that predict progression of residual disease after ablation of extra-abdominal desmoid fibromatosis.European radiology · 2025Article
- The Desmoid Dilemma: Challenges and Opportunities in Assessing Tumor Burden and Therapeutic Response.Current oncology (Toronto, Ont.) · 2025Review
- Article
- Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations in CTNNB1 or APC: A Multi-institutional Retrospective Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Magnetic resonance imaging patterns of tumor response to chemotherapy in desmoid-type fibromatosis.Cancer medicine · 2021Article
- Postoperative Adjuvant Radiotherapy Can Delay the Recurrence of Desmoid Tumors After R0 Resection in Certain Subgroups.Frontiers in surgery · 2021Article
- MRI T1 Contrast-Enhanced Signal Intensity Is a Prognostic Indicator of Imatinib Therapy in Desmoid-Type Fibromatosis.Frontiers in oncology · 2021Article
- Desmoid-Type Fibromatosis-Clinical Study of an Uncommon Disease.Indian journal of surgical oncology · 2020Article
- Aggressive fibromatosis response to tamoxifen: lack of correlation between MRI and symptomatic response.Clinical sarcoma research · 2018Article
- Current Update on Desmoid Fibromatosis.Journal of computer assisted tomographyReview
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the association of MRI features of extra-abdominal desmoid tumours (DTs) with prognosis.
methodsMRIs for 90 patients with DT were retrospectively reviewed for imaging features associated with biological behaviour. The primary end point was progression (for lesions managed with chemotherapy, radiation therapy and observation) or recurrence (following surgery). Time to event was studied using univariate and multivariable Cox proportional hazards regression models when accounting for demographic, clinicopathological and imaging variables. Kaplan-Meier plots were used to estimate event-free rate (EFR).
resultsUnivariate analysis revealed a significant relationship between EFR and treatment, location and compartment of origin [subcutaneous (SC), superficial fascial, intramuscular (IM) and deep fascial/intermuscular]. None of the imaging features commonly associated with biological behaviour of DTs (e.g., shape, enhancement, T2 signal etc.) or surgical margins (in surgical cases) was associated with EFR. Multivariate analysis showed that treatment modality and compartment of origin were independent predictors of EFR. Superficial and deep fascial lesions had a significantly worse EFR as a group [hazard ratio: 3.9; 95% confidence interval (CI): 1.83-8.32; p = 0.0004] than did the SC and IM lesions as a group. 5-year EFR for the fascial lesions was 18% (95% CI: 6-36%), compared with 57% (95% CI: 25-79%) for the SC and IM groups.
conclusionIntramuscular or SC DTs may be associated with improved prognosis. If validated on multireader and prospective studies, these results can provide for rapid risk stratification at the time of initial MRI. ADVANCES IN KNOWLEDGE: This work has shown that imaging features commonly associated with biological activity of desmoid tumours (e.g. shape, T2 signal and enhancement) do not appear to be associated with prognosis in patients undergoing a variety of treatment modalities. The compartment of origin of the lesion, which can be determined on pre-operative MRI, was shown to be associated with prognosis and can allow for risk stratification in patients with DTs.
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