ReviewHead and neck pathology2016
Phosphaturic Mesenchymal Tumor: 2 New Oral Cases and Review of 53 Cases in the Head and Neck.
Review in Head and neck pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Persistence and recurrence in tumor-induced osteomalacia: A systematic review of the literature and results from a national survey/case series.Endocrine · 2022Pooled it
- Clinical characteristics of tumor-induced osteomalacia lesions in the neurocranium and intracranial structures.Orphanet journal of rare diseases · 2026Article
- Spinal phosphaturic mesenchymal tumor: a case report of thoracic vertebral involvement with preoperative embolization and literature review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Calcified Chondroid Mesenchymal Neoplasm of the Temporomandibular Joint: A Rare and Recently Described Benign Tumor.Case reports in otolaryngology · 2026Article
- Hypophosphatemic osteomalacia secondary to jaw phosphaturic mesenchymal tumor: a case report with literature review.Frontiers in surgery · 2026Article
- Surgical treatment as a key determinant of outcome in phosphaturic mesenchymal tumors of the bone and soft tissue: a systematic review and case series.EFORT open reviews · 2025Article
- Mast Cell Association with the Microenvironment of a Phosphaturic Mesenchymal Tumour Secreting Fibroblast Growth Factor 23.Medical sciences (Basel, Switzerland) · 2025Article
- Successful cryoablation for a phosphaturic mesenchymal tumor in the maxilla causing tumor-induced osteomalacia: a case report.Archives of osteoporosis · 2025Article
- Primary Intraosseous Solitary Fibrous Tumor of the Mandible: Report of a Diagnostically Challenging Case with NAB2::STAT6 Fusion and Review of the Literature.Head and neck pathology · 2024Review
- Acquired hypophosphatemic osteomalacia: case series from a Peruvian referral center (1999-2023).Archives of osteoporosis · 2024Article
- FGF23-secreting sinonasal tumour presenting with acute subdural haemorrhage and tumour-induced osteomalacia.BMJ case reports · 2024Article
- Latent phosphaturic mesenchymal tumor in left planta detected by [European journal of nuclear medicine and molecular imaging · 2024Article
- Prolonged generalized osteomalacia associated with a sinonasal cavity phosphaturic mesenchymal tumor: A case report.Clinical case reports · 2024Article
- A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report.Translational cancer research · 2023Article
- Metastatic Malignant Phosphaturic Mesenchymal Tumor of Mandibular Alveolus: a Rare Case Report and Review of Literature.Indian journal of surgical oncology · 2022Review
- Phosphaturic Mesenchymal Tumor in the Maxillofacial Region: A Diagnostic Dilemma.Journal of maxillofacial and oral surgery · 2022Article
- Ameloblastic Fibroodontoma of Mandible Causing Tumor Induced Osteomalacia: A Case Report with Review of 88 Phosphaturic Oral Neoplasms.Head and neck pathology · 2021Review
- Stumbling upon the unexpected: A unique presentation of phosphaturic mesenchymal tumor in the hindfoot.Radiology case reports · 2020Article
- Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Clinical, histopathologic, subtype, and immunohistochemical analysis of jaw phosphaturic mesenchymal tumors.Medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm that secretes fibroblast growth factor-23 (FGF-23) and causes oncogenic osteomalacia. It occurs in adults with equal gender distribution and the most common location is the lower extremities, followed by the head and neck. Besides osteomalacia, the clinical presentation includes bone pain and multiple bone fractures. Microscopic features consist of spindle cells, multinucleated giant cells, and calcifications embedded in a chondromyxoid matrix. Laboratory findings indicate normal calcium and parathyroid levels, hypophosphatemia, and increased levels of FGF-23 that usually revert to normal after surgical removal. Due to its rarity, the purpose of the study was to report 2 new oral cases of PMT and to review the literature in the head and neck. The first case occurred in the gingiva and had been present for 6 years. The second case was a recurrence of a previously diagnosed PMT in the right mandible that metastasized to the lung and soft tissue. The literature review included 53 cases in the head and neck. There was a predilection for extra-oral sites (76%) compared to intra-oral sites (24%) with paranasal sinuses considered the most common location (38%) followed by the mandible (15%). There were 9 recurrences that included 3 malignant cases indicating a potentially aggressive tumor. Due to the indeterminate biological behavior of PMT and its rarity, a comprehensive evaluation of medical, laboratory, radiographic, and histological findings are crucial for a definitive diagnosis and treatment.
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