Evidence map›Paper›PMID 26577149›Full record

ReviewJournal of ovarian research2015

The Bologna criteria for poor ovarian response: a contemporary critical appraisal.

Johnny S Younis, Moshe Ben-Ami, Izhar Ben-Shlomo

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of ovarian research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06732843 (Does Recombinant FSH), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06732843 recruitingnot on this mapstarted 2025, after this paper: background citation

Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?

Typeobservational_patient_registrySponsorART Fertility Clinics LLCRan2025 to 2027Enrolled10ConditionsOVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  9. A Comparative Analysis ofLife (Basel, Switzerland) · 2025
    Article
  10. Article
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  14. Fertility history and intentions of married women, China.Bulletin of the World Health Organization · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Johnny S YounisReproductive Medicine Unit, Department of Obstetrics and Gynecology, Poriya Medical Center, Tiberias, 15208, Israel. jyounis@poria.health.gov.il.
Moshe Ben-AmiReproductive Medicine Unit, Department of Obstetrics and Gynecology, Poriya Medical Center, Tiberias, 15208, Israel. mbenami@poria.health.gov.il.
Izhar Ben-ShlomoReproductive Medicine Unit, Department of Obstetrics and Gynecology, Poriya Medical Center, Tiberias, 15208, Israel. ibenshlomo@poria.health.gov.il.
Poriya Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postponement of child bearing and maternal age at first pregnancy are on the rise, contributing considerably to an increase in age-related infertility and the demand for assisted reproductive technologies (ART) treatment. This brings to the infertility clinics many women with low ovarian reserve and poor ovarian response (POR) to conventional stimulation. The Bologna criteria were released to standardize the definition of POR and pave the way for the formulation of evidence-based, efficient modalities of treatment for women undergoing IVF-ET. More than four years have passed since the introduction of these criteria and the debate is still ongoing whether a revision is due. Women with POR comprise several sub-groups with diverse baseline distinctiveness, a major issue that has fueled the discussion. Although antral follicle count (AFC) and anti-Müllerian hormone (AMH), are considered good predictors of ovarian reserve, their threshold values are still not universally standardized. Different definitions for sonographic AFC and diverse assays for AMH are held responsible for this delay in standardization. Adding established risk factors to the criteria will lead to more reliable and reproducible definition of a POR, especially in young women. The original criteria did not address the issue of oocyte quality, and the addition of risk factors may yield specific associations with quality vs. quantity. Patient's age is the best available criterion, although limited, to predict live-birth and presumably oocyte quality. High scale studies to validate these criteria are still missing while recent evidence raises concern regarding over diagnosis.

Indexed as

Anti-Mullerian HormoneAntineoplastic AgentsDiagnostic ErrorsEvidence-Based MedicineFemaleHumansInfertility, FemaleMenopause, PrematureMenstrual CycleMutationOocytesOvarian CystsOvarian FollicleOvarian ReserveOvulation InductionPostoperative ComplicationsAnti-Mullerian HormoneAntineoplastic Agents

Identifiers

PMID26577149
PMCPMC4650906
OpenAlexW2179266619

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.